A. Patel

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

The paper identifies dominant immune system archetypes across 364 tumors from 12 cancer types using flow cytometry and transcriptomic data, linking them to tumor biology classifications.

This study uses multi-omics profiling to analyze U2AF1 mutations in myeloid malignancies, revealing altered RNA binding, splicing, and stress granule formation.

This study develops a qPCR assay to measure Klebsiella colonization density in rectal swabs and finds that higher density is significantly associated with increased infection risk.

This study finds that gut microbiome features, including increased Enterococcus and total bacterial abundance, and decreased butyrate-producing bacteria, are associated with sepsis onset and mortality.

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

This study discovers and characterizes skeletostatins, selective skeletal myosin II inhibitors with improved properties for research and drug development.

This study evaluates an intradermal DNA vaccine against SARS-CoV-2 in rhesus macaques, showing it induces immune responses and provides protection against viral challenge.

The paper describes a rapid serological assay to detect functional antibodies blocking ACE2 recognition in vaccinated animals and infected patients.

This paper shows deltaviruses diversify by shifting between mammalian hosts, with evidence from sequence data and field studies in bats.

This study determines the structure and dynamics of ACP-AT interactions in E. coli FAS using crystallography, MD simulations, and biochemical analyses, revealing flexible conformations and subdomain motions critical for catalysis.

This study establishes a pig influenza model to evaluate monoclonal antibody efficacy against H1N1, showing dose-dependent reduction in viral load and lung pathology.

The paper identifies Tae5STM as a T6SS effector with L,D-carboxypeptidase activity that cleaves peptidoglycan, revealing a new superfamily of bacterial effectors involved in interbacterial competition.

The paper identifies a quiescent-like state, Neural G0, in human neural stem cells and gliomas using scRNA-seq, linking it to tumor aggressiveness and survival.

This study compares serum proteomics and B-cell repertoire sequencing in rabbits immunized with beta-galactosidase, finding proteomics captures more antibody diversity and partially complements sequencing.

This study shows how biopolymer filaments alter the shape and structure of protein droplets by affecting surface tension and viscosity.

This study identifies two distinct LUSC subtypes driven by Sox2 partnerships with Brn2 or p63, revealing lineage heterogeneity and potential therapeutic targets.

The paper develops a recombineering-based toolset for high-throughput gene tagging in plants, enabling precise chromosomal modifications and efficient generation of transgenic lines.

This study introduces functionalized microcarriers that enhance T cell expansion, increase migratory memory T cell production, and improve the CD4/CD8 ratio compared to current methods.

The paper investigates the gating mechanism in β-ketoacyl-ACP synthases using structural and dynamic analyses to reveal how substrate discrimination occurs during catalytic reactions.

This study shows that PFK-1.1 dynamically forms liquid-like condensates in neurons under energy stress, revealing a new mechanism for subcellular organization.

This study shows that modifying the AP-2 adaptin complex in Plasmodium falciparum reduces susceptibility to artemisinin, suggesting alternative mechanisms of drug resistance beyond pfkelch13 mutations.

This study develops CRISPR-Cas9 genome editing in Plasmodium knowlesi to generate a transgenic line expressing P. vivax Duffy binding protein, showing its role in host cell tropism and vaccine potential.

This study shows that azithromycin combined with ceftriaxone improves survival in a murine sepsis model by reducing inflammation, not by antibacterial effects.

The paper shows KHS101 inhibits HSPD1 in glioblastoma cells, causing metabolic dysfunction and tumor growth reduction without affecting normal cells.