H. Kim

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

This study examines how substrate stiffness affects barrier function in iPSC-derived BBB endothelial-like cells, finding enhanced TEER on compliant substrates and no effect on P-glycoprotein activity.

This study identifies ERELEE4 as an ORA59-binding cis-element and shows ORA59 regulates JA/ET-responsive genes through direct promoter binding, with differential preference for GCC box and ERELEE4 based on hormone activation.

The paper computationally designs and improves a protein binder targeting HER2 domain IV, achieving a two-orders-of-magnitude increase in binding affinity through iterative computational and experimental feedback.

This paper reveals that Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome through H2O2-mediated control of GAPDH activity.

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

The paper investigates the role of Spc1 in yeast, showing it shields transmembrane segments from signal peptidase cleavage, thereby influencing substrate selection.

The paper identifies synergistic genetic targets in Ph-like B-ALL using network analysis to guide combination therapy, showing improved efficacy in preclinical models.

This study identifies transcriptome changes in Chlorella sp. HS2 under high salinity stress, revealing lipid accumulation and halotolerance mechanisms through carbon reallocation and NADPH co-factor regulation.

This paper develops a platform for remote biochemical monitoring using microparticle-based biosensors and OCT, enhanced by deep learning for 3D time series data analysis.

The paper identifies therapeutic genetic variations in Hsp104 homologs that specifically counter proteotoxicity in yeast, human cells, and C. elegans by enhancing passive chaperone activity.

This study identifies cholesterol's essential role in SARS-CoV-2 membrane fusion and syncytia formation, suggesting statins may benefit COVID-19 patients.

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

This study evaluates compounds targeting SARS-CoV-2 proteases Mpro and PLpro, finding limited efficacy for Mpro due to off-target inhibition of host cathepsins and no viable hits for PLpro.

This paper introduces a self-sterilizing PPE material that deactivates SARS-CoV-2 in 30 seconds, outperforming conventional copper configurations.

This study encodes multiple virtual signals in DNA barcodes using single-molecule FRET, enabling the differentiation of six barcodes without sequence exchange.

The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

This paper identifies TgSPY as the O-fucosyltransferase in Toxoplasma gondii, showing it modifies proteins but is not essential for growth, yet affects protein levels and virulence in mice.

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

This study uses multiomics analysis of LGSOC cell lines to identify therapeutic vulnerabilities and biomarkers for MEK inhibitor efficacy.

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

This study investigates whether XMAP215 and γ-tubulin synergize in microtubule nucleation and finds they act additively, not synergistically, in purified solutions.

This study identifies SDE2's role in stabilizing the TIMELESS-TIPIN complex to protect stalled replication forks and maintain genomic integrity.