J. Zou

The paper assesses the neutralization ability of BNT162b2-elicited sera against SARS-CoV-2 variants, finding that all sera neutralize variants to titers of ≥80, indicating vaccine effectiveness against emerging strains.

This study shows TET1 facilitates DNA demethylation of the Cxcl1 promoter, enabling its induction and neutrophil recruitment during acute lung injury.

This study shows that immunization with different SARS-CoV-2 variant spikes leads to varying neutralizing kinetics and magnitudes against other variants, with significant differences in titers between homologous and heterologous variants.

This study identifies the molecular mechanism of CPC-Sgo1 interaction and shows its role in centromere localization and function through structural and functional analyses.

This study uses single-cell transcriptomics to identify novel cell populations and functional differences in human nucleus pulposus during degeneration, revealing potential regenerative and immunosuppressive roles.

This study identifies MLL4's role in promoting epidermal differentiation and ferroptosis, linking it to tumor suppression and skin homeostasis.

This study develops yolk sac-like organoids from hiPSCs to generate multipotent hematopoietic progenitor cells in a scalable and xeno-free system.

The paper evaluates the neutralization effect of BNT162b2 vaccine-elicited sera against SARS-CoV-2 variants with specific spike mutations.

This paper develops a trans-complementation system to produce single-round infectious SARS-CoV-2 at BSL-2 labs, enabling safe high-throughput testing without full viral replication.

The paper assesses the neutralizing activity of BNT162b2 vaccine-elicited sera against N501Y and Y501 SARS-CoV-2 variants, finding equivalent neutralizing titers.

This paper develops a high-throughput assay using a nanoluciferase-modified SARS-CoV-2 virus to rapidly test neutralizing antibodies and antiviral drugs.

This study shows that a western-style diet impairs gut microbiota's ability to clear bacterial pathogens, leading to chronic inflammation and insulin resistance.

This study shows the D614G mutation in SARS-CoV-2 increases viral replication and upper respiratory tract viral loads but does not reduce vaccine efficacy or antibody neutralization.

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

This paper develops a scalable, high-fidelity in vitro model of human cardiac development using hPSCs, showing high similarity to fetal hearts in morphology and cell-type complexity.

This paper introduces SPD-NGS, a method using phage display libraries to deeply profile protease substrate specificity, identifying cleavage sites and natural substrates with high coverage and accuracy.

This study identifies sexual dimorphism and female-biased sex ratios in Salix purpurea through multi-environment field trials and genetic family analyses.

This study analyzes pangolin coronaviruses to assess their role as potential intermediate hosts of SARS-CoV-2, finding genetic relatedness but not direct origin.

This study identifies sex pheromone plasmids as a mechanism for disseminating linezolid-resistance in E. faecalis through plasmid transfer.

This study shows that IL-22 and IL-18 prevent and cure rotavirus infection by distinct mechanisms involving cell extrusion and pyroptosis in intestinal epithelial cells.

The paper investigates the structure and organization of the Mto1/2 complex, revealing its multimeric architecture and the role of specific domains in dimerization.

This study reveals how Drosophila CAL1 targets CENP-A to centromeres via structural interactions with CENP-A/H4 and CENP-C, bypassing the need for the Mis18 complex.

This study identifies Borealin as the key mediator of Chromosomal Passenger Complex (CPC) chromosome association through direct nucleosome binding, revealing its critical role in chromosome segregation.

This study shows amino sugars like GlcNAc and GlcN enhance the competitiveness of commensal oral streptococci against S. mutans, reducing its viability in co-cultures and biofilms.

The paper uses germline genetic variants from exome sequencing data to predict tumor recurrence in ER+ breast cancer patients, finding gene signatures associated with recurrence and immune-related pathways.

The paper combines proteomics and machine learning to generate a high-confidence apicoplast proteome in malaria parasites, identifying 346 proteins and validating novel functions.

This study investigates how daclatasvir impairs HCV replicase assembly by disrupting NS4B-involved protein interactions and altering replicase quaternary structure.

The paper identifies a ternary TAF11/TAF13/TBP complex and reveals a novel regulatory state in TFIID function through structural and biochemical analyses.