P. Wan

Direct β1/β2 AMPK activation reduces liver steatosis but not fibrosis in a mouse model of non-alcoholic steatohepatitis

This study evaluates BI9774, an AMPK activator, in a mouse model of NASH, finding it reduces liver steatosis but not fibrosis and causes cardiac side effects.

DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction

This study identifies that DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junctions, suggesting MMP-9 as a potential therapeutic target for severe dengue.

Minutes-timescale 3D isotropic imaging of entire organs at subcellular resolution by content-aware compressed-sensing light-sheet microscopy

This paper introduces a computational light-sheet microscopy method that rapidly images entire organs at subcellular resolution, achieving high isotropic spatial resolution and significantly improved throughput.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

MACS: Rapid aqueous clearing system for three-dimensional mapping of intact organs

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

Fast, 3D isotropic imaging of whole mouse brain using multi-1 angle-resolved subvoxel SPIM

The paper was withdrawn due to inaccurate descriptions of other techniques in the manuscript.

STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.