K. Cui

Epsins oversee smooth muscle cell reprogramming by influencing master regulators KLF4 and OCT4.

This study shows Epsins regulate smooth muscle cell reprogramming by modulating OCT4 and KLF4, with implications for coronary artery disease.

VviWRKY10 and VviWRKY30 co-regulate powdery mildew resistance through modulating SA and ET-based defenses in grapevine

This study shows VviWRKY10 and VviWRKY30 regulate powdery mildew resistance in grapevine by modulating SA and ET defenses, with mutual transcriptional inhibition between the two genes.

Targeting endothelial FOXO1 protects diabetic β-cells and improves wound healing

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance

This study shows that palmitic acid induces mTORC1 activation via Tip60-mediated Rheb acetylation, leading to insulin resistance, while unsaturated fatty acids do not.

Membrane-remodeling protein ESCRT-III homologs incarnate the evolution and morphogenesis of multicellular magnetotactic bacteria

This study identifies ESCRT-III homologs in magnetotactic bacteria, showing their role in membrane remodeling and multicellular morphogenesis through genomic and imaging analyses.

Targeting Epsins by nanotherapy regulates lipid metabolism and promotes ABCG1-mediated cholesterol efflux to fortify atheroma regression

This study shows that targeting Epsins in macrophages with nanotherapy reduces lipid uptake and increases cholesterol efflux, promoting atheroma regression.

Targeting Epsins to Inhibit FGF Signaling while Potentiating TGF-beta Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis

This study identifies epsins as promoters of endothelial-to-mesenchymal transition in atherosclerosis and shows that a therapeutic peptide targeting epsin-FGFR1 interaction reduces EndoMT and atherosclerosis progression.

A human disease model of SARS-CoV-2-induced lung injury and immune responses with a microengineered organ chip

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

Modeling SARS-CoV-2 infection in vitro with a human intestine-on-chip device

This paper develops an intestine-on-chip model to study SARS-CoV-2 infection, showing intestinal damage and immune response similar to human infection.

Crl activates transcription by stabilizing the active conformation of the master stress factor σS

This study determines the structure of an E. coli transcription activation complex and shows that Crl stabilizes σS to activate transcription without DNA contact.