S. Kim

This paper investigates how the geometry of synthetic TCR agonists affects T cell activation, finding that ligand height, not epitope, determines potency.

This paper introduces a mean shift algorithm for drift correction in single molecule localization microscopy, improving accuracy in 2D and 3D imaging.

The study identifies NMD-mediated degradation of BrFLC2 mRNA as the cause of early flowering in oilseed-type Brassica rapa LP08 plants.

The paper develops a classification system to identify PPARγ ligands and categorize chemicals as white or brite adipogens using RNA-Seq and lipid accumulation data.

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

This study characterizes triolein's behavior in bilayer membranes and proposes a model for its role in lipid droplet biogenesis through membrane curvature induction.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

The paper evaluates the effectiveness of TMPRSS2 and RdRp inhibitors against SARS-CoV-2 variants B.1.1.7 and B.1.351, finding they are equally effective as against the original isolate.

This study shows that optimal mechanical noise and boundary tension in zebrafish embryos ensure robust somite formation and body segmentation.

This study identifies PGE2 production via COX-2 as a cytosol-dependent innate immune response critical for CD8+ T-cell priming against L. monocytogenes.

This paper develops a GelMAL hydrogel for encapsulating stem cells with tunable properties and cleavable crosslinks, preserving stem cell markers.

The paper introduces a model showing DNA supercoiling drives a transition between cooperative and antagonistic RNA polymerase dynamics during gene synthesis.

This study elucidates the molecular mechanism of substrate recognition by the macrocyclase PsnB in graspetide biosynthesis, revealing key interactions and structural features.

This study shows ecosystem size and complexity equally influence riverine biodiversity across different regions.

This study analyzes the blood microbiome in a porcine model of fecal-induced peritonitis, finding stable bacterial populations and taxonomic differences between fecal and blood microbiomes.

The paper introduces ORACLE, a multiplexed reporter system for live imaging of cell fate dynamics in hPSCs, revealing insights into pluripotency exit and early differentiation.

This study develops a RBD-based nanoparticle vaccine against SARS-CoV-2 that protects ferrets from infection and reduces viral load.

The paper develops a model-based method to measure acoustic radiation force of ultrahigh frequency ultrasonic transducers using gelatin phantom experiments and validates it with FRET live cell imaging.

The paper identifies heme auxotrophy in the acI bacterial lineage and shows it is widespread in uncultivated microbial groups, suggesting heme could enhance microbial culture diversity.

The paper uses optical diffraction tomography to image and analyze 3D vasculogenesis in vitro without exogenous labeling.

This study shows that acute Myc suppression in adult mice prevents KRasG12D-driven lung and pancreatic cancers with minimal side effects when applied metronomically.

This paper introduces a phenotype-based drug response metric that improves pharmacogenomic analysis by providing time-independent and phenotype-relevant assessments of drug effects.

This study shows that platycodin D inhibits SARS-CoV-2 infection by blocking lysosome- and TMPRSS2-driven entry through membrane cholesterol redistribution.

This paper introduces thin-chip microfluidic devices with integrated valves, demonstrating their utility in high-resolution imaging and single-cell applications.

This study examines how cigarette smoke and COPD affect SARS-CoV-2 infection by analyzing ACE2 and TMPRSS2 expression in human and mouse lung tissues and an in vitro model.

This paper demonstrates high-resolution imaging of FDG uptake in a 3D tumor-stroma model using radioluminescence microscopy, showing significant FDG uptake in both tumor and stromal compartments.

This study shows that ClpA does not need to rotate relative to ClpP for proteolysis, though some flexibility may aid function.

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

This study shows that adding acyclovir to chemoradiation reduces viability of EBV-infected NPC cells by increasing TK and apoptosis markers.

This study characterizes ocular biometrics and retinal function in rhesus macaques, finding similarities to human eyes, particularly in macular structure and cone photoreceptor function.