S. Kim

This study quantifies the biophysical differences in SARS-CoV-2 and SARS-CoV-1 RBD-ACE2 interactions using single-molecule force spectroscopy and SMD simulations, revealing a key N-glycan interaction in SARS-CoV-2 that enhances binding affinity.

This paper tests KDS2010, a reversible MAO-B inhibitor, in PD animal models and finds it effective with low toxicity and superior neuroprotection compared to selegiline.

This study compares qPCR and ddPCR for SARS-CoV-2 detection, finding ddPCR more sensitive and accurate in quantifying viral RNA from various sources.

The paper identifies stereotypic VH clonotypes against SARS-CoV-2 RBD in patients and healthy individuals, showing their pre-existing presence in the healthy population.

This study shows CDK2 activity coordinates cell-cycle commitment and DNA replication timing, with commitment occurring before DNA replication.

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

This study theoretically examines how fluid-to-solid tissue transitions control morphogenetic flows and shape during vertebrate body axis elongation, showing that tissue surface tension and fluid-solid transitions determine unidirectional elongation.

This study evaluates the anti-inflammatory and anti-calcification effects of Entelon150(R) in a beagle dog model of bovine pericardium implantation, finding reduced calcium content and inflammation.

This study develops a computational framework to describe embryonic tissue dynamics, revealing a tension-fluctuation-driven rigidity transition.

This study identifies distinct B cell signatures and tertiary lymphoid structures in HPV+ and HPV- HNSCC, highlighting their role in antitumor immunity.

The paper identifies a novel activation switch loop in Plexin-B1 that enhances its GAP activity towards Rap1b through a cooperative mechanism involving conformational changes.

The paper identifies miR-24-3p as a regulator of DNA damage responses and COPD susceptibility, showing its suppression in COPD and its role in modulating apoptosis and DNA repair.

This paper shows that the ClpXP protease regulates the abundance of σAntA, an ECF σ factor controlling antimycin biosynthesis in Streptomyces.

This paper introduces DNA micro-disks with index and WORM memory features to improve DNA-based data storage reliability and accessibility.

This study generates a TBT-bp2 knockout medaka strain to investigate the function and detoxification mechanisms of tributyltin-binding proteins.

The paper identifies Linc00402 as a novel lncRNA regulating allogeneic T-cell responses through RNA-seq analysis of human T-cells post-HSCT.

This study identifies USP9X as a deubiquitylase that regulates ZNF598 stability, impacting ribosomal quality control through modulation of di-ribosome resolution.

This study shows miR-155 shifts PGE2/PGD2 balance towards an oncogenic state by regulating enzymes involved in prostaglandin synthesis.

This study screens 48 FDA-approved drugs for antiviral efficacy against SARS-CoV-2 and identifies 24 drugs with IC50 values between 0.1 M and 10 M, including niclosamide and ciclesonide.

This study identifies mitochondrial complex II disruption in intestinal epithelial cells as a key driver of T-cell mediated intestinal immunopathology across multiple disease models.

This study compares the sensitivity of primer-probe sets for detecting SARS-CoV-2 RNA in N and Orf1 genes, identifying the most sensitive sets for each.

This study identifies TM4SF5's role in modulating SIRT1 and STAT3 signaling during NAFL to NASH progression, showing age-dependent effects and potential therapeutic targets.

This study develops a computer vision method to analyze C. elegans swimming behavior and identifies genetic factors influencing exercise-induced quiescence.

This paper develops a biosensor capable of continuously measuring multiple analytes in live animals with high sensitivity and temporal resolution, demonstrating its use for glucose and insulin detection in diabetic rats.

This study examines the relationship between gut microbiota composition and monocyte recovery after hematopoietic stem cell transplantation, finding no significant association in a small cohort.

The paper benchmarks predictive models for kinase inhibitor potencies using crowdsourced data and identifies new compound-kinase interactions.

This study develops an anti-somatostatin receptor 2 antibody-drug conjugate (ADC) that effectively targets and kills neuroendocrine tumors with minimal toxicity.

This study shows that the MyD88-Syk axis drives inflammatory responses in macrophages by promoting ROS/RNS generation and phagocytic activity through Src, F-actin, and Rac1.