S. Kim

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

This study identifies a GSK-3 interacting domain in SARS-CoV-2 N protein that enhances its phosphorylation, with mutations in variants like Delta and Omicron increasing N abundance and phosphorylation.

This study quantifies how Omicron variant's RBD mutations enhance binding affinity to ACE2 compared to the original SARS-CoV-2 strain.

This study examines how exercise affects stem cell compartments and immune cells in aging mice, identifying rejuvenating effects and transcriptomic changes.

The paper identifies BMP1 isoforms with opposite abundance patterns in NSCLC and control plasma proteomes, suggesting differential regulation linked to disease progression.

The paper identifies affinity-matured antibodies that neutralize SARS-CoV-2 Omicron with high potency and resolves their structure to explain cross-neutralization.

This study shows that IL-30, a subunit of IL-27, has a regulatory role in autoimmune inflammation, with its expression by APCs limiting inflammation, while dendritic cell-derived IL-30 is not required for disease development.

The paper shows that LAT condensates form in response to pMHC:TCR binding events, with condensation probability linked to binding dwell time and a mutation affecting this process.

This study identifies NUP210 as a metastasis susceptibility gene in ER+ breast cancer, showing its role in mechanosensation through heterochromatin-mediated disruption of mechanotransduction.

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

This study investigates how seipin's transmembrane segments contribute to triglyceride nucleation and lipid droplet budding using simulations and cell experiments.

This paper develops a label-free adaptive optics method for SMLM, enabling deep-tissue super-resolution imaging in whole animals by correcting tissue aberrations.

This study uses a coarse-grained model to investigate the biophysics of lipid droplet formation, showing that membrane rigidity and asymmetric tension influence TG nucleation and budding direction.

The paper develops a whole yeast-based oral vaccine against Eimeria tenella in chickens, showing reduced parasite replication and improved weight gain in vaccinated birds.

This study produces recombinant monomeric human IL-22 and shows it reduces DSS-induced colitis and pro-inflammatory cytokines in mice.

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

This study shows that ETEC's EatA protein degrades the host MUC2 mucin barrier, enabling bacterial access to enterocytes and toxin delivery.

This paper develops a method using clustered gas vesicles and spectral imaging to enable multiplexed ultrasound imaging for visualizing different species of gas vesicles at the single-cell level.

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

This study investigates how genome divergence and compatibility contribute to the stabilization of hybrid genomes in an allopolyploid plant species.

This study shows that IPMK in intestinal epithelial cells protects against colitis by regulating tuft cell development and cholinergic signaling.

This study shows that neutrophil-epithelial interactions enhance SARS-CoV-2 infectivity and pro-inflammatory responses in airway epithelium.

This paper identifies ONG41008 as a TGFβ biogenesis inhibitor with potent anti-fibrotic and anti-inflammatory effects in IPF and inflammatory models.

DEEP-MAP uses deep learning and multi-day microscopy data to predict cell fate dynamics in hPSCs without cell state reporters.

This study uses molecular dynamics and experiments to analyze how mutations in SARS-CoV-2 variants affect their binding to ACE2, identifying which variants are more contagious.

This study develops a strategy using solubility enhancers to produce soluble and bioactive human enterokinase in bacteria.

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

The paper extends CHARMM-GUI Membrane Builder to model and simulate lipid nanoparticles with ionizable cationic lipids and PEGylated lipids, showing how PEG-lipids affect membrane structure and dynamics.

This study identifies unique nuclear import and chromatin engagement mechanisms of AR-V7 in castrate-resistant prostate cancer, suggesting a Hit-and-Run transcriptional mode.

This study investigates the interaction dynamics between Rc-PYP and PBP, revealing a novel photochromic UV sensor mechanism and its potential use in optogenetics.