H. Liang

The paper identifies ATAC-seq peaks associated with smoking history in lung adenocarcinoma that correlate with patient survival and are linked to key oncogenic pathways.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study identifies two distinct processive motions of FtsW in E. coli, driven by FtsZ treadmilling or septal peptidoglycan synthesis, revealing a two-track model for sPG synthesis regulation.

This paper develops a nanoparticle-mediated method to enable in vivo analysis of RAS protein activity by delivering a fluorescent GTP analog into cells.

This study combines in silico and in vitro experiments to show that AQP3 facilitates unsaturated glycerol transport through concerted movement of two glycerol molecules despite high substrate affinity.

The paper analyzes synonymous sites in SARS-CoV-2 genes to assess translational efficiency trends and their implications for viral adaptation and epidemic growth.

This paper develops an in vivo protein kinase analysis method using chemical genetics and nanoparticle-mediated ATP analog delivery, demonstrating its applicability to AKT1.

This study compares TIP3P and TIP4P water models in simulating erythrocyte aquaporins using molecular dynamics and experimental validation.

This paper engineers Escherichia coli to convert ethanol into acetyl-CoA and its derivatives through a heterologous pathway, achieving efficient ethanol consumption and production of PHB and prenol.

This study shows that Scutellaria baicalensis extract and its compound baicalein inhibit SARS-CoV-2 replication and 3CLpro activity in vitro.

This study defines the caveolar lipid profile using quantitative lipid mapping and simulations, showing how CAV1 and cavin1 sort distinct lipids and create a unique lipid environment.

The paper identifies HCSs associated with AT-less type I PKSs through genome mining and reveals their diversity across strains and soil samples.

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.

The paper develops a mathematical model to predict cell division planes in plants and animals by simulating soap-film minima, showing it matches observed division sites and avoids unfavorable junctions.

The paper identifies DNA-damaging proteins in E. coli and their human homologs, showing they promote endogenous DNA damage and are overrepresented in cancer drivers.

This study shows bile acids like DCA alter lipid nano-assemblies in the plasma membrane, promoting EGFR clustering and MAPK signaling in Caco-2 cells and human intestinal enteroids.

This study identifies canonical and non-canonical ISGs in bat cells with distinct temporal expression kinetics, revealing unique aspects of the IFN response that may contribute to viral resistance.

The paper uses in silico SELEX to study mutational robustness of an L-Arm binding aptamer, finding two functional genotype neighborhoods with similar binding affinity to the wild-type.