J. Park

This paper introduces a hydrogel-based method for long-term label-free 3D imaging of live bacteria, enabling precise analysis of biophysical parameters and antibiotic responses.

This study identifies VNTRs as modifiers of breast cancer risk in BRCA1 185delAG carriers, finding several VNTRs significantly associated with earlier age of onset compared to SNPs.

This study identifies KDM4A as a key driver of neuroendocrine prostate cancer progression and shows that targeting KDM4A inhibits tumor growth in preclinical models.

This paper shows that MYC overexpression in cancers suppresses immune surveillance by inhibiting pro-inflammatory macrophages, and this immune evasion can be reversed by combined PDL1 and CTLA4 blockade.

The paper identifies kinesin adaptors that mediate spectrin transport and lattice expansion during axon stretch-growth.

This study shows that transcranial focused ultrasound can induce both suppressive and excitatory responses in an epilepsy model, depending on stimulation parameters.

This study compares high- and low-level deep learning approaches for microsatellite instability prediction using TCGA data, finding the high-level approach superior and identifying key morphological features.

The paper withdraws due to the need for further experiments to validate conclusions about Bfl-1 and HDAC inhibition in diffuse large B cell lymphoma.

The paper visualizes the tubulin folding pathway mediated by TRiC using cryoEM, showing how TRiC's structure guides the folding of β-tubulin through specific interactions.

The paper defines the high-resolution timeline of secretory vesicle formation and fusion in S. cerevisiae, revealing the ordered recruitment and release of key components.

The paper generates a high-quality little skate genome and analyzes motor neuron gene regulation across species to identify conserved and divergent mechanisms in vertebrate locomotion evolution.

The paper develops a platform for multi-scale molecular imaging and phenotyping of the human brain, integrating novel tools for tissue processing, imaging, and computational reconstruction.

This study shows intermittent fasting activates AMPK in rodent PAH models, improving RV lipid metabolism, mitochondrial function, and microtubule structure.

The paper measures dissolved siderophore concentrations and types in the North Pacific Ocean, linking their distribution to microbial activity and environmental factors.

The paper presents a high-resolution structure of the S1P5 receptor complexed with an inverse agonist, revealing structural features that explain receptor subtype selectivity and inverse agonism.

This paper introduces a new sample delivery method for serial femtosecond crystallography, enabling reliable crystal deposition and successful structure determination of lysozyme.

This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.

The paper shows that abiotic reactions drive most N2O production in tropical peatlands, forming a coupled abiotic-biotic cycle with microbial N2O reduction.

This study characterizes translocation renal cell carcinoma (tRCC) through integrated clinical and molecular analysis of 152 patients, identifying key features like MiT/TFE fusions, NRF2-driven antioxidant response, and differential treatment outcomes.

This study tracks endoscopic changes in IL-10 knockout mice and finds that 40% do not develop colitis, with all cases resolving spontaneously.

This study evaluates variant-specific LNP-mRNA vaccines against SARS-CoV-2, showing differential neutralization and immune responses in animal models.

The paper shows that Prochlorococcus in iron-depleted regions uses siderophores for iron uptake, with this trait more common in the North Pacific than the North Atlantic.

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

The paper introduces a multi-camera array microscope (MCAM) that enables high-resolution, multi-scale imaging of behavior and neural activity in model organisms.

The paper proposes a deep learning algorithm for detecting hollow heart in potato tubers using consumer-grade hardware, achieving improved classification performance compared to human scoring and X-ray methods.

This study shows an inactivated multivalent influenza A vaccine provides broad protection against diverse IAV subtypes in mice and ferrets, including non-vaccine strains, suggesting its potential as a universal vaccine.

This study identifies spartin as a receptor mediating selective autophagy of lipid droplets and links its dysfunction to Troyer syndrome.

This study shows that capicua (CIC) regulates thymic T cell development by controlling positive and negative selection and TCR signaling, preventing autoimmunity.

This paper develops a framework for rapid bacterial species identification using 3D quantitative phase imaging and artificial neural networks, achieving 99.9% accuracy with single colony-forming units.

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.