M. Yuan

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

The paper examines how mutations at E484 and K417 in SARS-CoV-2 variants affect neutralizing antibodies, showing reduced efficacy against certain antibody families but not others.

This study shows that combining cross-neutralizing antibodies CV38-142 and COVA1-16 enhances neutralization of SARS-CoV-2 and SARS-CoV pseudoviruses.

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

The paper investigates how microtubules and Gαo-signaling regulate the preferential secretion of newly synthesized insulin granules in β cells, showing that their absence leads to increased secretion of older granules.

This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.

This study uses single-cell RNA-seq to analyze stromal vascular fraction cells in cancer-related lymphedema, identifying lineage-specific changes and potential therapeutic targets.

This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.

The paper introduces a framework to quantify microbial community assembly mechanisms in grassland soils under warming, finding homogeneous selection and drift dominate, with warming altering their relative contributions.

This study identifies ceftazidime as a drug that inhibits SARS-CoV-2 infection by blocking the spike protein-ACE2 interaction in vitro, with an IC50 below therapeutic blood concentrations.

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

The paper identifies a SARS-CoV-2 antibody that cross-neutralizes SARS-CoV by binding a conserved epitope and relies on avidity for neutralization.

This study identifies an alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 RBD, showing that longer CDR H3 can bind with different angles and interactions.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study shows that pattern-recognition receptors (PRRs) are essential for NLR-mediated immunity in plants, revealing a unified model where PTI supports ETI during bacterial infection.

This study shows remdesivir reduces renal fibrosis in obstructed kidneys without affecting renal or liver function.

This study examines cross-reactive antibody responses between SARS-CoV-2 and SARS-CoV, finding common binding but rare neutralization, suggesting non-neutralizing antibodies target conserved epitopes.

Structural study of a cross-reactive SARS antibody reveals a conserved epitope on the SARS-CoV-2 receptor-binding domain.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

This paper compares random forests and artificial neural networks for predicting dengue cases in Colombia, finding that random forests provide more accurate forecasts, especially when applied nationally to local data.

This study shows that immunization with B41 and BG505 SOSIP trimer immunogens in rabbits induces distinct autologous neutralizing antibody lineages targeting overlapping glycan hole epitopes, but broadening reactivity remains challenging.