Q. Chen

This study identifies G-CSF as a metabolic niche factor that replenishes Pax7Hi muscle stem cells in aged mice through exercise-induced mechanisms.

This paper proposes a runaway mutation model explaining how mutator mutations can lead to escalating mutation rates in both germline and somatic tissues, affecting evolutionary strategies across species.

This paper develops a syngeneic mouse model of tobacco-associated HNSCC that shows high response rates to anti-CTLA-4 therapy.

This paper develops a CRISPR-based colorimetric gene detection platform using AuNPs that enables naked-eye detection of DNA and RNA targets with high sensitivity and universality.

This study identifies Pkd2p, a TRP channel in fission yeast, as a regulator of cytokinesis by modulating osmotic homeostasis and cell separation.

The paper examines codon substitution rates across species and finds that evolutionary rates are strongly negatively correlated with amino acid distance under predominant negative selection.

The paper shows that siRNA with a 5-nucleotide motif suppresses DNA-mediated IFN and cytokine signaling by inhibiting IFI16-DNA binding.

This study identifies two regions on MiD51 that bind Drp1 and shows that MiD51 dimerization via a disulfide bond is required for Drp1 recruitment, revealing a multi-faceted regulatory mechanism for mitochondrial fission.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

The paper shows that positive selection drives amino acid substitutions with large chemical property changes, while negative selection favors smaller changes, suggesting distinct evolutionary mechanisms.

The paper introduces an M-value to quantify mitochondria-lysosome contact and mitophagy using structured illumination microscopy, finding distinct M-value ranges for these processes.

The paper shows that mother centrioles are not required for deuterosome formation and function during basal body amplification in multiciliate cells.

This paper develops a CRISPR/Cas9-edited CHO cell line deficient in MGAT1 to produce HIV-1 gp120 with early glycosylation intermediates, enhancing binding to glycan-dependent broadly neutralizing antibodies.

The paper develops an iridium(III) dye for tracking mitochondrial dynamics under structured illumination microscopy, revealing new insights into mitochondria-lysosome interactions.

This study shows that Elongator regulates SHORT ROOT transcription in Arabidopsis roots, essential for stem cell maintenance and radial patterning.

This study identifies a de novo BK channel mutation causing epilepsy by enhancing voltage-dependent activation, while not affecting calcium sensitivity.

The paper develops a computational model of peptide-capped gold nanoparticles, validated by experiments, revealing new structural features of monolayers.