S. Das

This study investigates how succinimide formation in an archaeal glutaminase enhances thermostability through structural and computational analysis.

HSF-1 recruits MET-2 to increase H3K9me2 levels at daf-2, silencing the insulin-like receptor and enhancing offspring stress resilience in C. elegans.

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

The paper shows that exogenous V12Rac1 enhances alveolar F-actin and prevents TNFR1 surge, reducing mortality in ALI caused by LPS or Pseudomonas aeruginosa.

This study uses liver electrical impedance tomography to detect fatty infiltration in obese individuals, finding a negative correlation between EIT conductivity and MRI-measured fat fraction.

The paper demonstrates that BioCompute Objects (BCOs) enable high concordance (99.15%) in replicating NGS analysis results across simulated regulatory submissions and reviews.

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

This study shows that Chromogranin A regulates gut permeability through the opposing actions of its proteolytic peptides CST and PST.

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

This study shows GIV/Girdin dampens TLR4-mediated inflammatory responses in macrophages by inhibiting receptor dimerization and downstream signaling.

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.

The paper links lung microbiota composition to clinical outcomes in transplant recipients by identifying four distinct microbial states associated with immune activity and lung function.

This study shows that CST reduces hypertension and cardiac inflammation by suppressing macrophage activity in mice.

The paper shows that bromelain peptides from pineapple inhibit Aβ fibrillation and dissociate preformed fibrils, reducing their cytotoxicity in cells and animal models.

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

The paper assesses TB prevalence, risk factors, and health-seeking behavior in tribal communities in Odisha, finding a 0.68% prevalence rate linked to cultural ignorance, alcohol use, and poor access to healthcare.

This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.

This study identifies DDX5 as a regulator of tissue-specific oncogenic RNAs in intestinal tumorigenesis, showing its role in promoting colon and small intestine cancers.

This paper identifies lipid imbalances caused by IDH1 mutations that lead to organelle dysfunction, with therapeutic implications for glioma treatment.

This study shows that GPR35 signaling in CX3CR1+ macrophages, mediated by lysophosphatidic acid, regulates intestinal cytokine production and inflammation.

This study uses coarse-grained MD simulations to show that DNA plectoneme pinning at mismatches is deterministic under high force and salt, but probabilistic under physiological conditions, with pinning probability increasing with mismatch size.

This study shows maternal serotonin signaling during stress in C. elegans protects offspring by enabling HSF1 to alter chromatin in germ cells, ensuring their viability and stress tolerance.

The paper shows that retromer facilitates the recycling of the copper transporter ATP7B from lysosomes to the Trans Golgi Network in a copper-dependent manner.

The paper assesses fecal contamination in urban Dhaka using E. coli MPN measurements across different environmental samples and finds higher contamination in low-income areas compared to high-income and transient neighborhoods.