S. Patel

This study shows that RORγt serine 182 regulates T cell heterogeneity in the intestine, maintaining homeostasis and limiting inflammation.

The paper shows that JG-98, an Hsp70 inhibitor, causes cell death by activating the eIF2α phosphorylation pathway through the Hsp70-Bag3 complex, linking ER and cytoplasmic proteotoxicity.

This study identifies key amino acids in extracellular loops 2/3 and transmembrane7 of GPR116 that are critical for tethered agonist-mediated activation.

This study shows GCN5 acetylates YY1, reducing its DNA binding and increasing dystrophin expression, which maintains muscle integrity in mice.

This paper uses deep learning and high-content screening of iPSC-derived cardiomyocytes to predict cardiotoxicity patterns in 1280 compounds and identify cardiotoxic chemical frameworks.

The paper compares antibody binding and neutralization against SARS-CoV-2 B.1 and B.1.351 variants in infected and vaccinated individuals, finding reduced titers but retained neutralization.

The paper documents metaplasia in wild eastern oysters from the Gulf of Mexico post-Deepwater Horizon oil spill, showing higher rates than Chesapeake Bay controls.

This study shows Kv1.3 is highly expressed in human PDAC and novel Kv1.3 inhibitors combined with chemotherapy significantly reduce tumor growth in mouse models.

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

This study shows that low doses of Ad26.COV2.S vaccine protect rhesus macaques against SARS-CoV-2 challenge, with higher doses needed for upper respiratory tract protection.

This study shows human urine alters MRSA virulence and transcriptome, affecting metabolic pathways, adherence, and surface properties.

This study compares the skin and gill microbiome of diploid and triploid Atlantic salmon, finding ploidy affects gill microbiome diversity and susceptibility to pathogens.

The paper shows that mammary ductal epithelial cells regulate cold-induced adipocyte thermogenesis via secreted factors called mammokines in female mice.

This study reconstructs the lineage histories and differentiation trajectories of JAK2-mutant HSCs in MPN patients, finding the mutation occurs decades before diagnosis and drives exponential growth of mutated HSC populations.

This study shows that mantis shrimp prioritize shape over color when recognizing objects, using the species Neogonodactylus oerstedii in controlled experiments.

This paper introduces a method using Nanotrap(R) particles to improve SARS-CoV-2 detection in pooled samples, saliva, and transport medium by concentrating virus before RNA extraction.

The paper identifies genetic vulnerabilities in WGD+ tumor cells and shows that KIF18A is specifically required for their viability.

This study shows that breast cancer cells with EMT features are more sensitive to the cytotoxic effects of ophiobolin A, suggesting its potential as a targeted therapy.

This study identifies a structural difference between serine and threonine phosphorylation, showing phosphothreonine adopts a compact, cyclic conformation with specific torsions.

The paper identifies how ecological, evolutionary, and eco-evolutionary feedbacks influence system stability using nine empirically-parameterized models of exploiter-victim systems.

This study identifies AtRAV1 as a transcription factor that interacts with MAP kinases to enhance disease resistance in Arabidopsis and tomato.

This paper identifies key intracellular metabolite changes in MCF-7 cells treated with doxorubicin using a novel vertical tube gel electrophoresis (VTGE) system and LC-HRMS analysis, revealing caspase 3-independent mitochondrial apoptosis.

The paper compares manual and automated lifespan assays in Caenorhabditis strains, finding that automated methods reproduce results but show assay-specific effects of chemical interventions.

The paper shows that multidimensional difference interactions with trait costs can mimic matching interactions in quantitative trait coevolution, suggesting the need to explore higher-dimensional trait spaces.

This study shows that inactivating GSK-3 and GSK-3β in thymocytes disrupts β-selection and positive selection, leading to T cell developmental defects and lymphomas.

This study shows metformin increases GDF15 levels, which is necessary for its weight loss and insulin-sensitizing effects in both humans and mice.

This study shows Toxoplasma gondii infection converts NK cells into ILC1-like cells that persist and circulate independently of infection.

The paper investigates eco-evolutionary feedbacks in a three-species apparent competition model, revealing how predator linkage disequilibrium influences prey coexistence and polymorphism maintenance.

This study uses replica exchange molecular dynamics simulations to investigate how mutations induce a disordered-to-ordered transition in Hahellin, a βγ-crystallin, revealing the role of ionic and hydrogen bonding interactions in stabilizing the ordered structure.

This study shows GFI1 acts as a tumor suppressor in colorectal cancer by reducing its expression in advanced stages and inhibiting tumor growth in models.