X. Huang

This study identifies miRNA193 in exosomes as a mediator of cisplatin resistance in esophageal cancer cells by regulating the cell cycle and inhibiting apoptosis.

This study challenges two established dogmas about bacterial cell growth and reveals a new linear relation between cell mass and division count across a wide range of growth rates in E. coli.

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

This study shows that loss of CHCHD2 and CHCHD10 activates OMA1, leading to mitochondrial cristae disruption similar to patient mutations, linking C10 pathogenesis to C2/C10 function.

This study investigates the role of ASK1/p38-mediated NLRP3 inflammasome signaling in diabetic retinopathy, showing its contribution to inflammation and aberrant retinal angiogenesis.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study characterizes the NF-κB protein in the sponge Amphimedon queenslandica, showing conserved features with vertebrates but distinct regulatory mechanisms.

This study quantifies selective pressures on human pigmentation genes across populations and time periods, finding directional selection on light and dark pigmentation traits.

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

This study develops the first low nanomolar LRH-1 agonist using structure-guided design, showing increased potency and anti-inflammatory effects in an organoid model.

This study identifies ZagA, a zinc metallochaperone in Bacillus subtilis, which interacts with FolE to sustain folate synthesis under zinc limitation, activated by the alarmone ZTP.

This study identifies and genotypes Trichosporon species isolated from giant pandas, finding 11 species with varying pathogenicity and genotypes.

This study investigates EAD properties in ventricular myocyte models, finding discrepancies between model predictions and experimental observations, particularly in inter-EAD intervals.

The paper introduces an open-source software tool for automated tracking of biopolymer networks in 2D and 3D using stretching open active contours, demonstrating its application in live cell studies.

The paper develops a platform to infer and validate signaling interactions at cellular resolution during C. elegans embryogenesis, identifying Notch interactions and their role in breaking fate symmetry.

This study identifies AMPKi as a compound that blocks 14-3-3 binding to CRAF, overcoming RAF inhibitor resistance by preventing paradoxical CRAF activation in cancer cells.