X. Huang

The paper introduces six mutants of β-glucosidase B and adds their catalytic activity and thermal stability data to the Design2Data database.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

This study identifies KDM4A's role in AML by showing its regulation of an epigenomic network critical for cell survival and self-renewal, and highlights a gene signature for risk stratification.

This study identifies CVB3 VP1 as an inhibitor of cell proliferation by disrupting MAT1 interaction with the CAK complex, thereby blocking CAK-CDK4/6-Rb signaling in pancreatic cells.

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

This study shows that combining MDM2 inhibitors and BET inhibitors synergistically kills AML cells by enhancing p53 activation through BRD4's repressive function.

The paper develops a phospholipid-mimicking LRH-1 agonist that shows in vivo efficacy in a colitis model by improving binding affinity and transcriptional activity.

This study maps QTL for leaf angle in maize using an F3:4 RIL population and identifies 24 candidate genes in two QTL regions.

This study examines how SARS-CoV-2 mutations affect protein structures and intraviral interactions, identifying mutations that cause structural changes and alter binding affinity and hot spots.

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

This study identifies CAR/Nr1i3 as a regulator of T cell adaptation to bile acids in the small intestine, showing its role in detoxification and inflammation resolution.

The paper shows that methylation of Aub by piRNA loading is essential for piRNA amplification and transposon silencing in Drosophila.

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

The paper identifies BnOCPA as an A1R agonist that selectively activates Gαob, providing analgesia without cardiorespiratory depression.

The paper investigates auxin and GA signaling crosstalk in wild strawberry fruit initiation, revealing conserved and novel mechanisms through genome editing and network analysis.

This paper introduces an amorphous nickel-titanium alloy film as a new supporting substrate for cryoEM, showing improved electron conductivity and reduced beam-induced motion, leading to better particle distribution and resolution.

This study shows miR-214 reduces pulmonary angiogenesis and alveolarization in BPD by inhibiting PlGF and STAT3 signaling in hyperoxic rat models.

This study shows that neuronal lipolysis prevents lipid droplet accumulation and alleviates neurodegeneration in C. elegans by regulating PUFA partitioning and phospholipid incorporation.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

The paper investigates the DPO-VqmA quorum-sensing pathway in Vibrio cholerae, revealing DPO-dependent and -independent activities of VqmA and structural insights into ligand binding.

The paper shows STAT3 localizes in mitochondria-associated ER membranes, not mitochondria, and other mitochondrial TFs also localize to MAMs.

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

This study identifies Qtip as a phage-encoded antirepressor that disrupts prophage repressor function and localizes to bacterial poles, revealing distinct mechanisms of quorum-sensing activation.

This study evaluates moxifloxacin efficacy against Mycobacterium abscessus in a zebrafish model, finding limited in vivo activity despite good in vitro results.

This study investigates the transcriptome changes in grass carp brains under low temperature, identifying key pathways and genes involved in cold acclimation.

The paper identifies ACPT gene inactivation in toothless and enamel-less mammals and estimates its inactivation times across different lineages.