G. Ma

Label-Free Electrochemical Imaging of Single Extracellular Vesicles

This paper introduces a label-free technique to quantify single extracellular vesicles by measuring their electrochemical impedance, enabling differentiation between cancerous and healthy cell-derived vesicles.

BRD8 guards the pluripotent state by sensing and maintaining histone acetylation

This study shows BRD8 maintains pluripotency by sensing and maintaining histone acetylation, preventing the conversion of primed EpiSCs to naive ESCs.

The effect of problem-based learning on improving problem-solving, self-directed learning, and critical thinking ability for the pharmacy students

This study evaluates problem-based learning (PBL) in pharmacy students, finding it improves problem-solving, self-directed learning, communication skills, and critical thinking compared to lecture-based learning.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

The Influence of Leaf Anatomical Traits on Photosynthetic in Coffee Leaves

This study quantifies how anatomical traits of Coffea arabica leaves influence photosynthesis using correlation and path analysis, identifying leaf thickness and stomatal density as key factors.

Single-Objective Evanescent Scattering Microscopy for Imaging Single Proteins and Binding Kinetics

This paper introduces single-objective evanescent scattering microscopy for label-free single protein imaging and binding kinetics quantification with high spatiotemporal resolution.

CsMYB4a from Camellia sinensis Regulates the Auxin Signaling Pathway by Interacting with CsIAA4

This study identifies CsMYB4a as a multifunctional transcription factor that regulates the auxin signaling pathway and phenylpropane/lignin pathways in Camellia sinensis.

Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense

This study shows the Nrf2/Keap1 axis is activated by EIAV-Rev, leading to antiviral effects through two mechanisms: enhancing antioxidant defenses and inhibiting Rev-mediated RNA transport.

Three-dimensional tracking of tethered particles for probing nanometer-scale single-molecule dynamics using plasmonic microscope

This paper introduces a plasmonic microscope technique for 3D tracking of tethered particles with sub-nanometer axial precision, enabling study of single-molecule dynamics and interactions.

Three bacterium-plasmid golden combinations facilitate the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

A programmable system to methylate and demethylate m6A on specific mRNAs

This paper introduces a CRISPR/dCas13a-based system to methylate and demethylate m6A on specific mRNAs, enabling targeted exploration of m6A's role in biological processes.

Population Pharmacokinetics of an Anti-PD-1 Antibody Camrelizumab in Patients with Multiple tumor types and model informed dosing strategy

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

Efficient detection of pre-proinsulin by double antibody sandwich ELISA

The paper develops a sandwich ELISA method using monoclonal antibodies to detect pre-proinsulin in recombinant human insulin production.

Parasites Acquired Beta Satellite DNAs from Hominid Hosts via Horizontal Gene Transfer

The paper identifies beta satellite DNA sequences in non-primate species, suggesting horizontal gene transfer from hominid hosts.

Optical imaging of single protein size, charge, mobility, binding and conformational change

This paper introduces a method to measure single protein properties like size, charge, mobility, and conformational changes using optical imaging and electric fields.

Time-resolved digital immunoassay for rapid and sensitive quantitation of procalcitonin with plasmonic imaging

This paper introduces a time-resolved digital immunoassay using plasmonic imaging to rapidly and sensitively quantify procalcitonin with a low limit of detection and wide dynamic range.

Development and Application of a High-Content Virion Display Human GPCR Array

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.