B. Wu

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This study shows RAD51AP1 binds nucleosomes and aids RAD51 in chromatin-mediated DNA repair by facilitating donor DNA capture and joint-molecule formation.

The paper shows evolution-based synthetic antigen designs can overcome pathogen diversity by generating broadly reactive OspC analogs against Lyme disease strains.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study shows that host immunity differences affect RNA virus evolution rates and patterns, with resistant hosts driving faster adaptation and permissive hosts selecting for specialist viruses.

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

The paper develops a SunTag-based reporter to study ribosome stalling during translation of poly(A)-containing mRNAs and finds that stalled ribosomes are slowly cleared by quality control machinery, targeting nascent proteins rather than mRNA.

The paper reports the cryo-EM structure of native human uromodulin, revealing its filamentous conformation and mechanism of bacterial binding.

The paper shows that dual localization of WHIRLY1 affects salicylic acid homeostasis by regulating ICS1, PAL1, and BSMT1 during Arabidopsis aging, leading to altered senescence phenotypes.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study shows that Aire's CARD-mediated multimerization forms nuclear foci and affects transcriptional activity, but also increases susceptibility to PML body interactions, which can impair its function.

This study shows that microbial adaptation reduces soil carbon loss under long-term warming by decreasing temperature sensitivity of respiration.

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

This study evaluates the prognostic role of c-Met overexpression in high-grade glioma through meta-analysis and finds it correlates with poor progression-free survival but not overall survival.

This study investigates the structural properties of alpha-lactalbumin and lactoferrin oleic acid complexes and their interaction with chromatin, suggesting potential anti-tumor mechanisms.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

The paper identifies isoform switching between mutant IDH1 and IDH2 as a mechanism of acquired resistance to IDH inhibitors in cancers.

This study analyzes four genomic biomarkers in 1,000 Chinese cancer patients to assess their distribution and associations with cancer types and mutations.

This study shows that macroH2A re-targets to heterochromatic domains in G1 phase after DNA replication, maintaining epigenetic memory through cell division.

The paper reports the crystal structure of the YTH domain of Mmi1 bound to DSR-containing RNA, revealing the mechanism of specific RNA recognition and its distinct function compared to other YTH domain proteins.

This study determines the crystal structures of hnRNPA2/B1's RRM domains bound to RNA substrates, revealing sequence-specific recognition and suggesting a matchmaker mechanism, but not m6A binding.