D. Huang

The paper examines how mutations at E484 and K417 in SARS-CoV-2 variants affect neutralizing antibodies, showing reduced efficacy against certain antibody families but not others.

This study analyzes SARS-CoV-2 genomes from early Canadian cases to trace viral origins and transmission patterns using phylogenetic analysis.

This study shows that combining cross-neutralizing antibodies CV38-142 and COVA1-16 enhances neutralization of SARS-CoV-2 and SARS-CoV pseudoviruses.

This study identifies five new Asgard archaeal phyla, expands the Asgard superphylum, and supports a 2-domain tree of life by showing Tyrarchaeota as a deeper branching lineage than Heimdallarchaeota.

This paper develops a catechol-functionalized oxime hydrogel to prevent post-surgical cardiac adhesions, showing improved tissue retention and reduced adhesion severity in animal models.

This paper develops a method to directly measure B lymphocyte gene expression in peripheral blood samples, enabling early prediction of vaccination response with high accuracy.

This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.

This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.

This study shows that interbacterial toxins like DddA can induce mutations in surviving bacterial populations, promoting adaptation through direct DNA mutagenesis.

The paper examines cross-reactive serum and memory B cell responses to SARS-CoV-2 and endemic coronaviruses, finding weak serum cross-reactivity but stronger memory B cell cross-reactivity.

This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.

The study examines how different low-temperature conditions affect microbial communities in an Anearobic-Anoxic-Oxic wastewater treatment process on the plateau, finding temperature impacts on specific bacterial abundances.

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

This paper introduces a MinION-based barcoding method for rapid and cost-effective species identification from macrofaunal samples on ARMS, achieving high accuracy and speed compared to traditional methods.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

This study rapidly identifies potent SARS-CoV-2 neutralizing antibodies and demonstrates their protective efficacy in an animal model.

The paper shows that dual localization of WHIRLY1 affects salicylic acid homeostasis by regulating ICS1, PAL1, and BSMT1 during Arabidopsis aging, leading to altered senescence phenotypes.

This study investigates how Duox and TLR3 genes in Hermetia illucens larvae suppress zoonotic pathogens by modulating intestinal bacterial community homeostasis through immune signaling pathways.

This study shows remdesivir reduces renal fibrosis in obstructed kidneys without affecting renal or liver function.

This study shows that removing mutant TP53 does not affect cancer cell survival, proliferation, or metastasis, suggesting GOF effects are not universally required for malignant growth.

This study shows that engineered HIV bnAb-expressing B cells can be expanded in vivo after vaccination, leading to durable bnAb memory and long-lived plasma cells.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

This paper uses solid-state NMR to show that 150 kDa Aβ(1-42) oligomers contain both parallel and antiparallel β-sheets with a unique inter-strand registry shift.

The paper demonstrates that authentic naive human VRC01-class BCRs can be primed and recruited to germinal centers in multiple mouse models, validating germline-targeting vaccine design.

The paper evaluates de novo-designed two-component nanoparticles for presenting HIV Env trimers, showing improved antibody responses through multivalent display.

The paper shows that air mass origin affects airborne microbial diversity at the Great Barrier Reef, with oceanic and continental trajectories influencing bacterial and fungal composition.

This study investigates how YTHDC1 binds to m6A-containing RNA motifs using simulations and experiments, revealing flexible 5 terminus interactions and conformational shifts.

The paper defines reference ranges for spot urine copper excretion in preschool children and identifies optimal cutoff values for pre-symptomatic Wilson’s disease screening.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.