F. Gong

The ICF2 gene Zbtb24 specifically regulates the differentiation of B1 cells via promoting heme synthesis

This study shows that Zbtb24 regulates B1 cell differentiation via heme synthesis, leading to impaired antibody production in T-cell independent responses.

Longitudinal analysis of memory T follicular helper cells and antibody response following CoronaVac vaccination

This study tracks memory T follicular helper cells and antibody response after three doses of CoronaVac vaccine over 300 days, showing increased neutralizing antibodies and cTFH cells, with correlation between cTFH and antibody titers.

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

This study shows metformin reduces TNF-α production in B cells of PCOS patients and mice by inhibiting mTOR and altering metabolism.

BiTSC^2: Bayesian inference of Tumor clonal Tree by joint analysis of Single-Cell SNV and CNA data

BiTSC2 jointly analyzes single-cell SNV and CNA data to infer tumor clonal trees with high accuracy and robustness to low sequencing depth.

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

Poly(ADP-ribose)-binding and macroH2A mediate recruitment and functions of KDM5A at DNA lesions

This study identifies PAR-binding and macroH2A1.2 as factors that mediate KDM5A recruitment to DNA damage sites, enhancing its repair and transcriptional functions at chromatin breaks.