J. Yu

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

The paper identifies an antisense RNA, NQO1-AS, that promotes breast cancer metastasis by stabilizing NQO1 mRNA, enhancing oxidative stress tolerance and enabling lung colonization.

This study identifies HOXB13's AR-independent role in suppressing lipogenesis via HDAC3-mediated epigenetic repression, linking its loss to metastatic prostate cancer progression.

This paper shows metformin reduces anxiety and depression-like symptoms in mice during methamphetamine withdrawal by modulating gut microbiota-derived inosine.

This study evaluates the protective efficacy of oral SARS-CoV-2 delivery in rhesus macaques against respiratory challenges, finding limited immunogenicity and partial protection.

This study identifies an adjuvanted SARS-CoV-2 RBD nanoparticle that induces neutralizing antibodies and full protection in aged mice.

The paper develops a 1,2-dicarbonyl compound that selectively activates Nrf2 at sites of oxidative stress, reversing pain in mice and offering a targeted approach for treating oxidative stress-related disorders.

This study investigates mCRP deposition in AAA and identifies associated proteomic changes and enriched pathways.

The paper compares five T cell expansion protocols and finds they induce distinct metabolic programs and phenotypes, with some conditions impairing T cell function despite metabolic adaptation.

This study compares two mRNA SARS-CoV-2 vaccines in nonhuman primates, showing that CV2CoV, with optimized non-coding regions, provides better immune responses and protection than CVnCoV.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study identifies metabolism as a key driver of hydrogen isotope fractionation in tree-ring glucose of Pinus nigra, showing it explains ~60% of deuterium variability.

This study uses computational methods to investigate how phage RNA polymerase evolves to switch promoter recognition from T7 to T3 through structural and electrostatic changes.

This paper describes a protein subunit vaccine candidate produced in yeast that protects non-human primates against SARS-CoV-2, showing high neutralizing antibody titers and reduced viral loads after challenge.

The paper identifies lncEry, a long non-coding RNA that regulates mouse erythroid differentiation and maturation by interacting with WDR82 to control Klf1 and globin gene transcription.

This study computationally examines how remdesivir nucleotide analogue binds and inserts into SARS-CoV-2 RdRp, showing it has a lower energy barrier than ATP insertion.

This study compares single-promoter and dual-promoter lentiviral vectors for CAR expression and cytotoxicity in engineered NK cells, finding that the single-promoter pCDHsp enhances expression and cytotoxicity.

This study identifies ERAD as a proteostasis checkpoint during β-selection, showing Sel1l deficiency causes ER stress and apoptosis, impairing β T cell development.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This paper reports the cryo-EM structure of antibody 5-7, which binds to a distinct site in the SARS-CoV-2 spike NTD, showing neutralization resistance to variants of concern.

This study shows that targeting developmental states in rhabdomyosarcoma can prevent disease recurrence by eliminating myoblast-like cells and inhibiting EGFR-dependent paraxial mesoderm populations.

This study evaluates the protective efficacy of rhesus adenovirus serotype 52 vaccines against a mouse-adapted SARS-CoV-2 strain, showing robust antibody responses and protection against viral replication and disease.

This study shows FXa cleaves SARS-CoV-2 spike protein, blocking viral entry, but B.1.1.7 variant is resistant, and FXa inhibitors like rivaroxaban reduce this protection.

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

This paper analyzes how the COVID-19 pandemic affected the publication landscape in CARi research, showing a slowdown in growth and changes in publication types and databases.

This study uses molecular dynamics simulations to reveal atomic-scale diffusion dynamics of the WRKY transcription factor along DNA, including base-pair stepping and strand preference.

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

This paper introduces an unsupervised deep learning method for cell segmentation from microscopy images, achieving accurate results without requiring labeled training data.

The paper characterizes the K18-hACE2 mouse model's response to different SARS-CoV-2 doses, showing dose-dependent disease severity and recovery, and compares it to human COVID-19 pathology.

The paper identifies the miR-424/503 cluster as a regulator of Wnt/β-catenin signaling in mammary epithelium by targeting LRP6, and links its loss to breast cancers with high Wnt/β-catenin activity.