M. Zhao

This study shows that PRC2-dependent epigenetic reprogramming in bladder urothelium worsens UTIs by promoting inflammation and impaired differentiation, and that inhibiting Ezh2 can improve disease outcomes.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

This study shows that JNK1/2 phosphorylates BNIP3 under hypoxia, enhancing its stability and promoting mitophagy by increasing its binding to LC3.

The paper shows that PI3K inhibition reverses single cell migration direction in electric fields but not in large cell groups, with different behavior observed in group interiors and edges.

This study identifies tembotrione-resistant sorghum genotypes, characterizes their resistance mechanism, and maps quantitative trait loci (QTLs) associated with metabolic resistance to this herbicide.

The paper identifies a mechanically stable knot in Zika virus RNA that enhances RNase resistance through specific folding mechanisms.

The paper examines how natural mutations in the SARS-CoV-2 pseudoknot affect −1 PRF efficiency and the activity of anti-frameshifting ligands, finding that ligand activity remains resistant to most mutations.

The paper models the structure of the SARS-CoV-2 frameshift stimulatory pseudoknot using computational methods and simulations, identifying multiple possible conformations.

The paper introduces TIPC, a computational algorithm that identifies tumor-immune spatial patterns in colorectal cancer, linking them to patient survival and tumor features.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

This study compares global chemical modifications in human plasma proteomes between young and old age groups, identifying four significant differences in modifications such as succinylation, phosphorylation, and carbamylation.

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

This study shows that RIP1 kinase activity in macrophages drives steatohepatitis by promoting cell death and inflammation, and its inhibition reduces liver injury in NASH models.

This paper demonstrates that gold nanorod-based delivery of Ramucirumab enhances cytotoxicity in gastric cancer cells through differential regulation of phagocytosis and Fcγ receptor expression.

The paper evaluates three 16S rRNA sequencing protocols for vaginal microbiome analysis and identifies biases in species abundance estimation, proposing an optimized protocol to improve accuracy.

This study identifies 51 T3E genes and seven novel T3Es in Acidovorax citrulli using bioinformatics and experimental validation, revealing its extensive T3E arsenal.

This study determines the structure of the zebrafish Gpr126 ECR, revealing a closed conformation stabilized by alternative splicing and a calcium-binding site, and shows how these features regulate receptor function.

This study compares in vitro and in vivo drug responses to Artesunate in HepG2 cells, finding discrepancies in efficacy and biomarker expression.

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

This study shows that ERAD preserves HSC quiescence and self-renewal by restricting mTOR activity, preventing HSC depletion and hyper-proliferation.

This paper shows that Salmonella infection creates electric fields in gut epithelium that guide macrophage migration, with directionality switching after phagocytosis.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.