S. Kumar

The paper identifies a genomic instability gene signature linked to poor survival in esophageal adenocarcinoma and validates its role in tumor growth and genomic instability.

The paper uses Raman imaging to show that intracellular vimentin unfolds under cellular tension, indicating IFs act as force sensors.

This study shows AMPK-Fyn signaling stabilizes cleaved Notch1 under hypoxia, enhancing breast cancer stemness and drug resistance.

This study shows that lipopolysaccharide treatment changes EV numbers and cargo in human lung-cancer cells and mice.

This study compares gene expression under heat stress in two Indian cattle breeds, finding Tharparkar better adapts through upregulated stress response and antioxidant genes.

This study uses computational methods to predict B- and T-cell epitopes on SARS-CoV-2 spike protein, identifying conserved peptides that may aid in peptide-based diagnostics.

The paper shows that the triphosphates of tenofovir and emtricitabine inhibit SARS-CoV-2 RNA-dependent RNA polymerase, suggesting potential use of DESCOVY and TRUVADA as PrEP for COVID-19.

The paper identifies hyperactive end joining repair in p53-deficient cells as a mechanism of resistance to DNA-damaging therapies and shows that combined inhibition of DNA-PK and Pol theta restores sensitivity.

This study identifies RRBP1 as a key regulator of cisplatin resistance in OSCC, showing its role in YAP-1 regulation and demonstrating that Radezolid can restore cisplatin sensitivity.

This study shows that three nucleotide analogues inhibit SARS-CoV-2 polymerase by being incorporated and blocking further RNA synthesis.

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

This study identifies Aurora B kinase-mediated phosphorylation of caspase-2 at S384, which inhibits its catalytic activity and apoptosis function during mitotic catastrophe.

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.

This study uses single-cell RNA sequencing to analyze the host and viral RNA dynamics during VEEV infection, identifying superproducer cells and candidate antiviral targets.

This study compares simple and complex substitution models for divergence time estimation, finding that simple models can produce similar results to complex ones in many datasets.

This study shows how altering graphene substrates' surface chemistry affects fibronectin structure, which in turn influences stem cell behavior and bone differentiation.

The paper identifies viral factors associated with early broadly neutralizing antibody (bnAb) responses in HIV-1-infected infants and suggests implications for polyvalent vaccination strategies.

The paper investigates the potential of nucleotide analogues, specifically EPCLUSA, as inhibitors of viral polymerases in coronaviruses like 2019-nCoV, SARS, and MERS.

This paper identifies H1t's association with repressed repeat-element chromatin domains in pachytene spermatocytes through ChIP-sequencing and mass spectrometry.

The paper introduces a new method to calculate reliable confidence intervals for divergence times estimated using the RelTime method, showing good coverage probabilities in simulations.

The paper designs a mini-core of 520 rice accessions that effectively represents the genetic diversity of 3004 rice accessions, capturing SNPs, phenotypes, and geographical regions.

This study compares pathogenic and non-pathogenic Xanthomonas strains to reveal evolutionary differences and genomic factors contributing to pathogenicity and host adaptation.

This study describes a new bacterial species, Xanthomonas sontii, isolated from healthy rice seeds, which is non-pathogenic to rice plants.

This study evaluates seven computational methods for inferring clone phylogenies from bulk sequencing data, finding significant variation in their accuracy for mutation order and clone grouping.

This study identifies Siliplant1 (Slp1) as a protein that precipitates silica in sorghum silica cells through in vitro and in vivo experiments.

The paper quantifies biophysical processes in choanoflagellate rosette morphogenesis, showing ECM constraints drive 3D growth and shape colony morphospace.

This paper introduces RTDT, a new method for inferring timetrees from temporally sampled molecular sequences, which is more accurate and computationally efficient than existing Bayesian methods.

The paper identifies genetic determinants of Plasmodium falciparum fitness across its life cycle using bulk segregant analysis and experimental crosses.

This paper introduces a modified evolutionary probability (EP) method that infers phylogeny and divergence times from sequence alignments, enabling reliable EP estimates without prior knowledge of species relationships.

This study evaluates the physicochemical and microbiological quality of spring water in Sikkim, revealing severe fecal contamination and heavy metal exceedances, posing immediate health risks.