S. Kumar

The paper analyzes codon usage patterns in SARS-CoV-2 to suggest a single transmission event from a codon-optimized virus and hints at hybrid origins and the role of silent mutations in its evolution.

This study isolates and characterizes Lumpy Skin Disease Virus (LSDV) from cattle in India, showing it is closely related to Kenyan strains and demonstrating alternative cell lines for virus isolation and propagation.

This paper develops and characterizes an mRNA-LNP vaccine candidate targeting the D614G variant of SARS-CoV-2, showing neutralizing antibody and balanced cellular immune responses in preclinical trials.

The paper reconstructs the progenitor SARS-CoV-2 genome and traces its evolution and spread globally, showing multiple dominant strains and lineage replacements in different regions.

A dominant-negative mutation in phototropin1 increases carotenoid content and alters metabolite and protein profiles in tomato fruits.

This study investigates resveratrol's binding to an oncogene promoter DNA sequence using spectroscopic and molecular dynamics methods, revealing it binds to the minor groove near AT basepairs.

This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

This paper develops a tunable hydrogel for iPSC-derived vascular network formation and shows that stiffness modulation affects vascular growth.

This study shows that mechanical deformation of fibrin induces structural changes that affect its biochemistry and platelet interactions, revealing a mechano-chemical feedback loop.

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

The paper uses 4-PHF parameters to classify onion seedlots into storability groups, finding AUC as crucial for accurate categorization beyond conventional germination metrics.

The paper tests drug activity against SARS-CoV-2 in Vero E6 cells and finds ambroxol and ciprofloxacin effective at clinically relevant concentrations.

This study identifies a small-molecule amyloid inhibitor that disrupts mutant p53 aggregation, restores its function, and reduces tumor growth in xenograft models.

This study compares the resistance of SARS-CoV-2 RNA terminated by Sofosbuvir and Remdesivir to exonuclease proofreading, finding Sofosbuvir-terminated RNA more resistant.

This study uses coherent Raman microscopy to examine how shear and tensile forces affect fibrin molecular structure at different strain levels.

The paper uses single-cell RNA and chromatin accessibility data to show disturbed flow reprograms endothelial cells from atheroprotective to pro-atherogenic phenotypes.

This study evaluates traditional and improved grain storage technologies in Indian farming communities using a hybrid multi-attribute approach to assess their performance and guide improvements.

This study identifies novel transcription terminators in maize that enhance transgene expression by overlapping poly(A) signals, with specific motifs like AUGAAU showing functional significance.

The paper identifies unique mutations in SARS-CoV-2 strains from India, suggesting an attenuated pathotype with implications for vaccine development.

This study investigates how Mg2+ ions facilitate RNA folding through coordinated water molecules, showing that Mg2+ enables efficient folding while other ions like K+ and Ca2+ do not.

The paper identifies miR-7 as a modulator of T cell activation by showing its enrichment in HMW-RISC and its role in suppressing IL-2 signaling and metabolic processes.

This paper demonstrates efficient, marker-free gene targeting in maize using inducible CRISPR-Cas9 and a donor template, achieving high mutation rates and heritable results in the T0 generation.

The paper identifies hPDGFRβ as a host receptor for the malaria parasite TRAP, showing its role in sporozoite motility and infection.

This study shows that adipocyte signals can drive iWAT browning through macrophage-like cells, independent of sympathetic nerves.

The paper identifies a rare L184F mutation in HIV-1 Env that destabilizes the trimer apex, leading to escape from broadly neutralizing antibodies targeting the V2 apex.

The paper investigates signal bias at glucagon family receptors, showing biased agonists affect intracellular signaling and insulin secretion differently.

This study investigates how mutations in the multibasic cleavage site of SARS-CoV-2 spike protein affect interactions with host proteases, suggesting potential strategies for attenuating the virus and developing antivirals.

This paper evaluates nucleotide analogues as inhibitors of SARS-CoV and SARS-CoV-2 RdRp, identifying those that terminate RNA synthesis and resist viral exonuclease activity.