Author

X. Luan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

H. E. Xu· 3 shared H. Jiang· 3 shared L. Zhang· 3 shared S. Zhang· 3 shared Y. Jiang· 3 shared D. Shen· 2 shared M. Gao· 2 shared W. Yin· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersBiophysics

H. E. Xu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lipid droplets restrict phagosome formation during Candida challenge

W. Sun, H. Wu, G. Zhao, Q. Shui, L. Zhang, X. Luan, T. Chen, F. Liu, Y. Zheng, W. Zhao, X. Qi, B. Liu, C. Gao

This study shows that lipid droplets restrict phagosome formation in macrophages during Candida infection, protecting cells from death and offering a potential drug target.

bioRxiv · Jun 11, 2024 · PreprintMicrobiology

Mesenchymal stromal cells and alpha-1 antitrypsin have a strong synergy in modulating inflammation and its resolution

L. Han, X. Wu, O. Wang, X. Luan, W. H. Velander, M. Aynardi, E. S. Halstead, A. Bonavia, R. Jin, G. Li, Y. Li, Y. Wang, C. Dong, Y. Lei

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

bioRxiv · Nov 19, 2022 · PreprintBioengineering

Universal mechanism of hormone and allosteric agonist mediated activation of glycoprotein hormone receptors as revealed by structures of follicle stimulating hormone receptor

H. E. Xu, Y. Zhang, S. Zhang, J. Duan, P. Xu, H. Zhang, X. Luan, J. Yang, Y. Ji, X. He, H. Jiang, X. Cheng, Y. Jiang, C. Mao, D. Shen

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

bioRxiv · Aug 1, 2022 · PreprintCell Biology

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

W. Yin, X. Luan, Z. Li, Y. Xie, Z. Zhou, J. Liu, M. Gao, X. Wang, F. Zhou, Q. Wang, Q. Wang, D. Shen, Y. Zhang, G. Tian, H. A. Aisa, , H. E. Xu

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

bioRxiv · Nov 1, 2020 · PreprintBiophysics

Structure Basis for Inhibition of SARS-CoV-2 by the Feline Drug GC376

X. Luan, W. Shang, Y. Wang, W. Yin, Y. Jiang, S. Feng, Y. Wang, M. Liu, R. Zhou, Z. Zhang, F. Wang, C. Wang, M. Gao, H. Wang, W. Wu, , S. Zhang

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

bioRxiv · Jun 7, 2020Biophysics