X. Xiao

This study identifies an unconventional voltage-sensing mechanism in TRPV1 channels where outer pore acidic residues, not the S4 segment, mediate voltage sensitivity and activation.

The paper reports an unexpectedly high mutation rate in Thermococcus eurythermalis, challenges the hypothesis of low mutation rates in hyperthermophiles, and links mutation rate to genome size and population dynamics.

This study analyzes Woesearchaeota distribution and diversity using 16S rRNA and metagenomic data, revealing their presence in host-associated environments and genomic variation across ecosystems.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

The paper shows that the ZBP1-IRF3 axis promotes myeloma cell proliferation by activating cell cycle genes instead of type I IFN responses.

The paper links myeloma initiating genetic events to chromatin accessibility and oncogenic transcriptomes, identifying critical enhancers regulating CCND2 expression.

This study identifies COUP-TFII as a driver of myofibroblast metabolic shift to aerobic glycolysis, promoting fibrosis in multiple organs.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

The study shows that organic manure and rice straw residue increase soil microbial diversity and abundance in double-cropping paddy fields compared to chemical fertilizer alone or no fertilizer.

The paper identifies differential RNA editing between epithelial and mesenchymal tumors and shows its impact on immune response pathways through ILF3-mediated transcript stabilization.

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

This study engineers an AAV9 capsid to bind serum albumin, improving liver transduction in mice after intravenous delivery.

This study shows that Salmonella Typhi produces two distinct typhoid toxin variants with different delivery components but shared active subunits, leading to functional versatility.

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

This paper investigates how biodiversity changes across spatial scales and introduces methods to better quantify these changes using rarefaction curves and case studies.

This paper develops a method to create 3D histological images of whole zebrafish using synchrotron X-ray micro-tomography, enabling cellular-resolution phenotyping without sectioning.

The paper introduces MoB, a method to decompose changes in species richness into components of abundance distribution, density, and spatial arrangement, and applies it to plant species data in invaded and uninvaded woodlands.

mobsim simulates biodiversity patterns and analyses sampling effects across spatial scales to improve biodiversity metric interpretation.

The paper compares four species-abundance distribution models using likelihood and AIC across 16,000 communities, finding the log-series model provides the best fit overall.