Y. Yu

This study identifies PARPi-induced degradation of lineage-specific oncoproteins as a mechanism for PARP1 inhibitor toxicity in SCLC, showing improved cytotoxicity when combined with targeted agents.

This paper identifies a Wnt/β-catenin-regulated extracellular matrix (ECM) program in adrenocortical carcinoma (ACC) that promotes tumor growth and shows that inhibiting this pathway reduces tumor viability and growth in preclinical models.

This study identifies epigenetic chemical probes that enhance TAK-243 cytotoxicity via off-target ABCG2 inhibition and develops a cell-based assay to measure ABCG2 inhibition.

This study identifies RNF114 as a key player in PARP1 trapping and shows that nimbolide blocks its degradation, enhancing PARP1 trapping and cytotoxicity in BRCA-deficient cancers.

This study develops a culture model to expand adult tubular microvessels on stiff substrates using endothelial cells and pericytes from the same tissue, showing improved growth and morphology with a custom medium.

The paper shows that convergent evolution of Omicron variants evades antibodies from BA.5 infections while maintaining ACE2 binding, driven by immune imprinting.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

This study shows that BA.4.6, BA.4.7, and BA.5.9 subvariants with R346 mutations evade humoral immunity more effectively than BA.4/BA.5, reducing neutralization titers by 1.5-2.6-fold.

This study shows influenza A virus directly alters Streptococcus pneumoniae's virulence and metabolism without host involvement, revealing inter-kingdom interactions that enhance bacterial pathogenicity.

The paper identifies a potent and broad sarbecovirus-neutralizing antibody cocktail, SA55+SA58, from SARS convalescents to combat Omicron variants and other fast-evolving viruses.

This study characterizes the enhanced infectivity and antibody evasion properties of the SARS-CoV-2 Omicron subvariant BA.2.75 compared to BA.5 and other variants.

This study investigates how bio-oil components affect phenol-formaldehyde resin properties using model compounds, showing phenols and ketones improve synthesis while aldehydes and acids have negative effects, but all components enhance aging resistance.

The paper shows human and avian influenza viruses use different glycoconjugate types for infection, with avian strains using a broader range.

The paper identifies circadian clock genes involved in parallel clinal diapause adaptation in two moth species, showing repeated use of the period gene with distinct alleles.

The paper investigates how the timing of phagosome transport from actin to microtubules affects the kinetics of early phagosome maturation and its transition to late phagosomes.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This paper develops an optical brain-computer interface using hippocampal calcium activity in mice to decode spatial, visual, and auditory information in real time with high accuracy.

The paper uses super-resolution imaging to show how Dectin-1 and TLR2 nanoclusters interact synergistically to enhance signaling in macrophages.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

The paper identifies persistent immune and clotting dysfunction in saliva and plasma of COVID-19 patients 4-6 weeks post-symptom resolution, highlighting saliva as a viable alternative to plasma for monitoring immune and inflammatory sequelae.

The paper shows lamin A/C enables nuclear deformation through fibrous environments by acting like surface tension, allowing nuclei to bypass obstacles without rupturing.

This study shows that Schwann cells activated by cancer cells form tracks that promote pancreatic cancer invasion through c-Jun-dependent mechanisms.

PPRD integrates and curates ~45,000 plant RNA-seq libraries into a searchable database to facilitate expression analysis.

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

This paper develops a biparatopic nanobody with broad neutralization against multiple SARS-CoV-2 variants, including Omicron, showing strong affinity and activity.

This study shows that DDX60 selectively inhibits translation from type II viral IRESs, reducing replication of EMCV and FMDV but not type I IRES viruses.

This study shows that interrupting central tolerance generates high-affinity T cells that avoid exhaustion and enhance cancer immunotherapy.

This study characterizes GR13 plasmids in Acinetobacter, showing their capacity to accumulate and horizontally transfer diverse accessory genes through dif modules and insertion sequences.

The paper determines the high-resolution structure of MgtE TM domain with Ca2+ and shows Mg2+ binds 500-fold stronger than Ca2+.

This study identifies how Omicron evades neutralizing antibodies by analyzing mutations and their effects on different epitope groups, showing over 85% of tested antibodies are escaped.