Z. Zhang

The paper shows that protoplast formation in Kitasatospora viridifaciens causes genetic changes including megaplasmid loss and chromosomal lesions linked to insertion sequences.

This study investigates hybrid fitness in yeast under environmental stress, finding selection against heterozygosity and positive epistasis between divergent species.

This study designs and characterizes bifunctional ligands that induce K-Ras association with immunophilin proteins, showing their efficacy in blocking B-Raf interaction and suggesting therapeutic potential for Ras-driven cancers.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This study uses DNA-origami structures to measure lipid transfer distances mediated by the SMP domain of E-Syt1, supporting a shuttle model over a distance exceeding the SMP dimer length.

This study identifies SKI-73 as a CARM1 chemical probe that reduces breast cancer cell invasion by altering epigenetic plasticity, distinct from CARM1 knockout effects.

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study shows that the carboxyl-terminal sequence of Bim is necessary for Bax activation and cell killing, independent of anti-apoptotic protein inhibition.

This study shows CEACAM1 regulates IL-6 production in murine monocytes via RP105, affecting the fever response to LPS.

This meta-analysis evaluates immunosuppressive treatment in IgA nephropathy, finding reduced proteinuria and ESRD risk but increased adverse effects.

The paper shows Rtn4a enhances exocytosis without altering ER morphology, while changes in ER tubule-to-sheet ratio do not affect protein trafficking or translation.

This study identifies EphA4 as a new Kaposi’s sarcoma-associated herpesvirus entry receptor, showing it promotes viral fusion and infection better than EphA2 in HEK293T cells.

This study identifies 11 new pelagiphages in the Podoviridae family that integrate into host SAR11 genomes, providing evidence of both lytic and lysogenic infection mechanisms.

The paper reports glendonite occurrences in the Tremadocian of Baltica, indicating massive ikaite precipitation under near-freezing conditions, conflicting with tropical temperature estimates from oxygen isotopes.

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

This study shows that placing a vein in contact with microporous calcium phosphate induces more luminal vascularization than surgical arteriovenous loop techniques.

The paper compares the sensitivity of four probe technologies to measure biomechanical properties of different cellular regions in two cell types under various perturbations.

The paper identifies MoRgs7 as a GPCR-like receptor in Magnaporthe oryzae that senses hydrophobic surfaces via hydrophobic interactions, couples with Gα subunit MoMagA for endocytosis, and promotes cAMP signaling required for appressorium formation and pathogenicity.

This study identifies KDM4D as a key regulator of hepatic fibrosis by modulating TLR4 signaling through histone demethylation in HSCs.

This study uses genomic data to show that TB clusters identified by traditional methods may persist for decades, and WGS reveals genetic factors that may enhance transmissibility.

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.

This study shows that O-GlcNAc homeostasis regulates cell fate decisions in hematopoiesis by affecting transcriptional programs and differentiation outcomes.

The paper uses an agent-based model to show that chemotaxis with adaptation explains M. xanthus cell aggregation and alignment during starvation.

The paper shows that elevated O-GlcNAcylation in CD4+ T cells enhances Th17 function by altering the lipid microenvironment, increasing IL-17A production in obesity.

This study identifies the molecular mechanisms and post-translational modifications governing the generation of distinct Nrf1α/TCF11 proteoforms and their involvement in feedback circuits with regulatory proteins.

The paper updates a group contribution method to estimate Gibbs energies and reaction equilibrium constants across temperatures and metal ion concentrations.

This study identifies topovectorial mechanisms that control Nrf1 proteolytic processing to generate mature CNC-bZIP transcription factor isoforms through ER-associated degradation.