C. Xu

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

The paper shows that specific small RNAs inhibit androgen signaling and induce cell death in prostate cancer cells by targeting AR-coregulatory genes through 3-UTR complementarity.

This paper develops a semi-supervised deep learning model for colorectal cancer recognition using pathological images, showing it outperforms supervised learning with limited labeled data and matches pathologists' performance.

This study reveals the structural mechanisms by which NLRP1 and CARD8 assemble distinct inflammasome complexes through unique CARD domain interactions.

The paper reports the cryo-EM structure of native human uromodulin, revealing its filamentous conformation and mechanism of bacterial binding.

This study investigates how HIV-1 capsid permeability to metabolites affects dNTP import and reverse transcription, revealing a mechanism involving IP6 and BHC.

This study determines the structure of the mammalian PA28β-iCP immunoproteasome using cryo-EM, revealing a unique mechanism of proteasome activation distinct from constitutive proteasomes.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This paper develops a sensitive and reusable method for detecting Exo III activity using DNB nanoarrays and cPAS sequencing technology, showing a linear response in low concentration ranges.

This paper develops an AI tool for colorectal cancer diagnosis using histopathology images, achieving high accuracy and consistency across multiple centers.

The paper identifies 291 protein complexes and 24,092 PPIs in Synechocystis sp. PCC 6803, revealing functional roles of previously uncharacterized proteins and their interactions across biological processes.

This study identifies Rv3194c as a hyaluronic acid-binding adhesin in Mycobacterium tuberculosis that facilitates lung epithelial interaction, with its binding site P91-110 serving as a potential therapeutic target.

The paper uses single-cell RNA-seq data to identify subclonal compositions in TNBC and links them to survival outcomes and immune microenvironment diversity.

The paper identifies the 20S proteasome's ability to degrade ubiquitin-tagged proteins under hypoxia and shows its role in improving cell survival.

This study shows Bmal1 integrates mitochondrial metabolism and macrophage activation, with implications for immunotherapy and inflammatory diseases.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This paper develops a method to produce human amniotic epithelial cells-only membrane with higher purity and clinical potential for wound healing.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

The paper visualizes the dynamic termination pathway of E. coli ribosomes with RF2 using cryo-EM, showing structural changes during protein release and RF2 dissociation.

This study presents two structures of SETD3 bound to β-actin peptides, revealing sequence-specific recognition and methylation mechanism.

This paper identifies the molecular mechanism by which MxB restricts HIV-1 by binding to the tri-hexamer interface of the viral capsid.

This study evaluates the effectiveness of maraviroc in preventing oral SIV transmission to infant macaques, finding only marginal impact despite CCR5 blockade.

This study shows Mycobacterium tuberculosis uses cytokinins, previously known as plant hormones, to induce gene expression affecting its cell envelope.

The paper demonstrates that SHR and stele-derived small peptides coordinate to rebuild functional Casparian strips in non-endodermal cells through two parallel signaling systems.

The persistence of hybrid ancestry is predictable from local recombination rates in three replicate hybrid populations and in humans.

This study evaluates carrion fly-derived DNA metabarcoding for mammal surveys, finding it detects more species than transect counts and camera-trapping in a known tropical mammal community.