BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer
W. Mi, J. You, L. Li, L. Zhu, X. Xia, L. Yang, F. Li, Y. Xu, J. Bi, P. Liu, L. Chen, F. Li
This study shows BET inhibition in liver cancer reduces proliferation by inducing GDH1-dependent glutamine metabolic changes, suggesting a therapeutic strategy combining BET and OXPHOS inhibitors.
bioRxiv · Mar 20, 2024Cancer Biology