X. Gao

The paper identifies compounds that inhibit SARS-CoV-2 3CLpro enzyme activity, with auranofin showing strong inhibition and potential for COVID-19 treatment.

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

This study compares the binding of SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins to glycans, finding HS binding is sulfation-dependent and sialic acid binding is absent.

This study uses molecular dynamics simulations to show that Remdesivir's 1-cyano group inhibits SARS-CoV-2 RdRp by disrupting nucleotide addition and proofreading, providing insights for drug design.

This study shows indomethacin inhibits SARS-CoV-2 pseudovirus in vitro and accelerates recovery in CCV-infected dogs compared to ribavirin.

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

The paper shows that B cells avidly bind to the Plasmodium CSP repeat domain, suppressing responses to protective epitopes, and that truncated CSP molecules induce broader immune responses and better protection.

The paper reports the structure of arrestin-2 bound to neurotensin receptor 1, revealing a novel orientation that enables coupling to GPCRs lacking a C-terminal tail.

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

This study compares protein metabolism and regeneration in diaphragm and gastrocnemius muscles of hibernating and summer-active Daurian ground squirrels, finding distinct regulatory patterns contributing to hypertrophy and atrophy.

This paper introduces a cost-effective, open-source hiPSC culture medium (B8) that reduces costs by 97% and allows weekend-free feeding without compromising growth or differentiation.

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

This study shows that estradiol and leptin modulate gut microbiota in female ob/ob mice on a high-fat diet, with E2 reducing microbial diversity and altering specific taxa.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

The paper uses computer simulations to show that gene circuits can evolve to maintain stable phenotypic switches by increasing potential barriers, ensuring adaptive alternatives are available during environmental stress.

This study uses a population model to test how aging-related changes in myocardial metabolites affect cardiac performance and energy metabolism in adult women.

The paper identifies 196 differentially expressed proteins in TGF-β1-treated lung fibroblasts and finds that VLDLR and SDC2 are upregulated in silica-exposed lungs, with knockdown reducing collagen production.

This study identifies and characterizes WRKY genes in melon, analyzes their evolution, and assesses their role in powdery mildew resistance.

The paper infers microbial interactions from longitudinal metagenomics data, finding differences in interaction patterns between healthy children and T1D progressors.

This study uses mechanical stimulation of suspended cell doublets to investigate how cortical actin and junction proteins respond to compression versus stretch at cell-cell contacts.