P. Luo

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Grifola frondosa polysaccharide Ameliorates Inflammation and Insulin Resistance by Regulating Macrophage Polarization of liver in Type 2 Diabetes Mellitus Rats

This study shows that Grifola frondosa polysaccharide reduces inflammation and insulin resistance in T2DM rats by modulating liver macrophage polarization.

IOBR2: Multidimensional Decoding Tumor Microenvironment for Immuno-Oncology Research

IOBR2 is a tool for analyzing tumor microenvironment using multi-omics data, offering modules for preprocessing, estimation, interaction analysis, and visualization.

THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research

THER is a web tool that integrates hypoxia-related transcriptomic data to analyze tumor hypoxia mechanisms and drug responses.

Illumination of the complement receptors C3aR and C5aR signaling by anaphylatoxins

This study reports the structures of C3a-bound C3aR and C5a-bound C5aR1, revealing their ligand recognition and activation mechanisms.

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

Impact of Pericytes on the Stabilisation of Microvascular Networks in Microfluidic Systems in Response to Nanotoxicity

This study shows pericytes stabilize microvascular networks in microfluidic systems, protect against stress and nanotoxicity, and improve in vitro model reliability.

Broad neutralization against SARS-CoV-2 variants induced by a modified B.1.351 protein-based COVID-19 vaccine candidate

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

S-Trimer, a COVID-19 subunit vaccine candidate, induces protective immunity in nonhuman primates

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

Emerging Concern of Scientific Fraud: Deep Learning and Image Manipulation

This paper shows GANs can generate realistic western blot images that fool researchers, highlighting the need for better detection methods and image verification protocols.

LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1

This study identifies LncRNA MIR4435-2HG as a mediator of cisplatin resistance in HCT116 cells via the Nrf2/HO-1 pathway.

Experimental infection characteristics of Bordetella pertussis via aerosol challenge on rhesus macaques

This study evaluates aerosol challenge of rhesus macaques with B. pertussis, showing similar infection characteristics to humans and supporting their use as a pertussis model.