C. Sun

This study isolates a marine fungus capable of efficiently degrading polyethylene, identifying degradation products and enzymes involved in the process.

This study identifies nanchangmycin as an anti-fibrotic agent that inhibits HSC myofibroblast activity by modulating FYN, FAK, and ERK signaling pathways.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study identifies a sulfate-reducing bacterium that forms zero-valent sulfur through sulfide oxidation, highlighting a new pathway in the sulfur cycle.

The paper identifies frequent allelic expression imbalance of PIK3CA mutations in breast cancer and links it to poor prognosis.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This paper develops a mathematical model of human circulation to simulate hemodialysis and therapeutic hypothermia effects on clinical measurables like blood pressure and heart rate.

The paper analyzes the epigenetic landscape of purified myonuclei from fast and slow muscles using ChIP-Seq, revealing distinct regulatory programs and transcription factor binding sites.

This paper describes the isolation and characterization of a novel deep-sea cold seep bacterium, Maribellus comscasis sp. nov., and highlights its genomic and phenotypic features distinguishing it from related species.

The paper isolates and characterizes a novel Chloroflexi strain, showing its role in sulfur cycling through assimilatory sulfate reduction.

The paper identifies a deep-sea bacterial threonine dehydratase that catalyzes cysteine desulfuration to produce hydrogen sulfide, revealing structural and functional mechanisms.

This paper isolates and characterizes a novel sulfate-reducing bacterium from a deep-sea cold seep, showing its ability to resist and remove heavy metals through sulfur cycling.

This study characterizes the first cultured free-living Candidatus Izimaplasma strain, revealing its unique DNA-degrading capabilities and ecological role in deep-sea methane seeps.

This study identifies a marine bacterial community capable of degrading PET and PE, elucidates its degradation mechanisms, and demonstrates its potential for bioremediation.

The paper shows Bacteroidetes are key to deep-sea carbon and nutrient cycling by degrading diverse glycans through metagenomics, isolation, and transcriptomic/metabolomic analyses.

This paper develops a pyrF-based genetic manipulation system for Acinetobacter baumannii, enabling efficient marker-less gene editing in multiple strains.

This study designs and tests RBD-conjugated nanoparticle vaccines against SARS-CoV-2, showing enhanced neutralizing activity compared to monomeric RBD.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study identifies the role of forehead gland secretions in conflict resolution among male Great Himalayan leaf-nosed bats through chemical analysis and behavioral experiments.

The paper investigates SARS-CoV-2 growth, furin-cleavage-site adaptation, and neutralization using serum from hospitalized COVID-19 patients, finding neutralizing antibody titers are comparable regardless of furin cleavage signal integrity.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study designs excretable AIE dots for deep-tissue imaging in marmosets, demonstrating their biocompatibility and excretion capabilities.

This paper introduces SDsSMLM, a spectroscopic single-molecule localization microscopy technique that improves spatial and spectral precision by symmetrically dispersing photons.

The paper uses snRNA-seq to analyze transcriptional diversity in multinucleated skeletal myofibers, revealing distinct myonuclear populations and novel gene markers.

This study develops an AI system to identify fetal nucleated red blood cells using deep learning, achieving high accuracy and sensitivity in testing.

The paper reports that Heimdallarchaeota, a group of archaea, possess proteins associated with photosynthesis and may perform oxygenic photosynthesis, suggesting a photomixotrophic lifestyle.

This study compares SARS-CoV-2 and SARS-CoV spike-RBD binding to ACE2, showing similar affinities but differing neutralizing antibody cross-reactivity, highlighting challenges for broad-spectrum vaccines.

This study analyzes DPANN archaea from deep-sea hydrothermal vents to understand their metabolism and ecological roles, revealing their genomic features and potential contributions to biogeochemical cycles.

This paper establishes an in vitro platform to study CD8+ T cell cytotoxicity against encapsulated cells via indirect antigen recognition, revealing that hydrogel encapsulation blocks direct T cell activation but allows indirect activation through host APCs.

This study determines the cryoEM structure of α-synuclein fibrils with the E46K mutation, revealing a more stable and pathogenic fibril structure compared to wild-type.