G. Zhang

The paper identifies Hippo kinases as inhibitors of PI3K alpha, showing epinephrine activates these kinases to suppress insulin signaling and glucose metabolism.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

The paper investigates how rhizobia move through Medicago truncatula root cells by analyzing the role of SyPME and NPL in cell wall modifications during infection thread progression.

This study investigates how Mikania micrantha responds to Puccinia spegazzinii infection using metabolomics and transcriptomics, identifying changes in metabolites and gene expression.

This study identifies and validates stable reference genes for RT-qPCR in Serratia ureilytica DW2 under various conditions.

This study evaluates the use of nanopore sequencing for SNP and cgMLST subtyping of Salmonella Enteritidis, showing high concordance with Illumina data despite sequencing errors.

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

This study uses culture-enriched phenotypic metagenomics to monitor clinically-important beta-lactam resistance genes in a wastewater treatment plant and river.

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This paper develops a chimpanzee adenovirus-based vaccine against the SARS-CoV-2 Delta variant and shows it induces strong immunity and protects mice from challenge.

The paper identifies BC5, an allosteric agonist that modulates BK channel activation by disrupting the coupling between Ca2+ binding and pore opening.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

This study uses a computational model to show how active forces between cells in a monolayer affect cell shape and collective motion, revealing contractile and extensile behaviors and their effects on tissue dynamics.

The paper uses long-read sequencing to identify novel transcripts and isoform changes in primate transcriptomes, highlighting immune-related regulatory divergence.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study samples C. elegans across Hawaii over three years, sequenced their genomes, and found seven genetic groups and 18 regions linked to local adaptation.

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

The paper evaluates variation in germline mutation rate estimates across labs using a standardized pedigree of rhesus macaques, highlighting methodological differences and the need for standardization.

The paper compares vaccine efficacy against Delta and Lambda SARS-CoV-2 variants, finding Lambda has greater escape potential, with reduced antibody reactivity and therapeutic antibody binding.

This study uses a simple neural network model to explore how information bottlenecks affect behavioral control, showing that modular connectivity improves efficiency but increases context-dependency.

This study identifies transcriptomic changes in cardiac fibroblasts associated with cardiac microthrombi in fatal COVID-19 through single nuclei RNA sequencing and clinical analyses.

This study uses dual-lipid metabolomics to compare lipid compositions of MTB and MB and their effects on bovine alveolar macrophages, revealing distinct metabolic responses and colonization mechanisms.

The paper detects pigeon circovirus in ticks collected from sheep and camels in Inner Mongolia using high-throughput sequencing and PCR, revealing its genomic sequence and phylogenetic classification.

This study identifies new CCHFV strains in Inner Mongolia, China, showing genetic similarities to strains from Xinjiang and South Africa, suggesting long-term prevalence in the region.

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

This study uses DNA barcoding and molecular phylogenetics to revise the genus Dichaetophora, identifying cryptic species and taxonomic issues within the group.