J. Ma

This study identifies O-GlcNAcylation at Thr221 as a constitutive inhibitor of TRPC6 channel conductance and NFAT signaling, showing its conservation and functional importance across TRPC family members.

This study identifies a remodeled RNA polymerase II complex that catalyzes viroid RNA-templated transcription, distinct from DNA-template Pol II complexes.

This study identifies the PPARγ/ETV2 axis as a novel pathway that suppresses endothelial-to-mesenchymal transition in pulmonary hypertension.

This study uses electron tomography to analyze the structural transformation of prolamellar bodies into grana thylakoids in Arabidopsis cotyledons and identifies the role of CURT1 proteins in this process.

This paper develops a ferritin-based nanoparticle vaccine targeting the SARS-CoV-2 Omicron variant, showing enhanced immunogenicity compared to a non-nanoparticle version.

The paper identifies CFS1 as an autophagy adaptor that connects autophagosomes with the ESCRT-I component VPS23 to form amphisomes, facilitating vacuolar delivery in plants.

This study uses HiFi metagenomic sequencing to assemble 102 complete MAGs from human fecal samples, achieving high nucleotide accuracy and capturing previously unculturable microbial genomes.

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

This study shows that IFITM3 protects mice from severe SARS-CoV-2 infection by limiting viral spread and inflammation, as demonstrated through knockout mouse models.

This paper develops a high-throughput fluorescence-based assay (SNTFLUO) for detecting yellow fever neutralizing antibodies, validated against WHO standards and applicable for differential diagnostics.

The paper shows that Slit-Robo signaling coordinates with S1P to polarize fin mesenchyme and establish fin morphology in zebrafish.

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

The paper identifies a cellular pathway involving Importin alpha-4 and Virp1 that facilitates nuclear import of noncoding RNAs, including viroids and a subviral satellite RNA.

This study uses electron microscopy to examine plastid conversion in Arabidopsis, showing CURT1A and CURT1C have distinct roles in etioplast to chloroplast development.

The paper fits a mosquito density model to Guangzhou data, identifies non-identifiable parameters, simplifies the model, and validates its applicability across seasons.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

This study uses polymer simulations to model how the diploid human genome organizes relative to nuclear bodies, showing that co-phase separation explains genome compartmentalization and spatial arrangement.

The paper identifies genomic features that determine the survival of HTLV-1 and HIV-1 clones in vivo, showing that radial chromatin organization, integration site, and host transcription influence clonal persistence.

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.

This study shows that Separase cleaves Meikin to control the meiosis I/II transition by altering its function and promoting Rec8 cleavage.

This study uses optical tweezers and molecular dynamics to analyze the mechanical unfolding kinetics of yeast tRNAphe, revealing how structural features influence folding and the role of tertiary interactions in unfolding cooperativity.

The paper identifies immune microenvironment subtypes in follicular lymphoma linked to tumor mutations and antigen expression, informing potential immunotherapeutic strategies.

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

This paper describes an interactive museum exhibit that synchronizes live human cardiomyocytes to visitor heart rates, engaging the public with heart biology and stem cell science.

This study shows that intestinal helminth infection alters CD4+ T cell composition in the skin, leading to long-term changes in immune responses to antigens.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

The paper investigates the immunogenicity of a public neoantigen derived from mutated PIK3CA, showing it is recognized by T cells and presents a framework for immunotherapy.