M. Wang

The paper identifies a cellular pathway involving Importin alpha-4 and Virp1 that facilitates nuclear import of noncoding RNAs, including viroids and a subviral satellite RNA.

This paper reconstructs the historical biogeography of early diverging termite lineages using genetic data, finding that their distribution resulted from both over-water dispersals and land bridge migrations.

This study uses mitochondrial genomes to show that Neoisoptera colonized Madagascar 7-10 times during the Miocene, matching Australia's colonization timing and sharing similar taxonomic composition.

This study presents cryo-EM structures of pancreatic KATP channels in closed and pre-open states, revealing nucleotide binding mechanisms and activation by Mg-ADP and diazoxide-type openers.

The paper introduces a robust beta regression method for dose-response curve estimation and develops a web tool for its implementation.

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

This study develops a human hepatic organoid model of ARPKD liver fibrosis, showing that the ARPKD mutation leads to fibrosis through TGFβ and PDGFRB pathways.

This paper identifies Mettl3 as a p53-interacting protein that stabilizes p53 and enhances its tumor suppressive functions through both protein stabilization and m6A modification of p53 pathway transcripts.

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

The paper introduces an improved BacMam vector for efficient and safe protein production in mammalian cells.

This study shows Tranexamic Acid inhibits cancer growth by blocking Plasmin-mediated CDCP1 cleavage and disrupts multiple intracellular signaling pathways.

This study shows that type IV pili in bacterial consortia reduce spatial intermixing, forming a bubble-jet pattern that affects community productivity.

This paper identifies a monoclonal antibody, 2-36, that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses, with a conserved epitope in the RBD identified through cryo-EM.

This study shows that loss of Nrf1, not Nrf2, causes lipid and ROS accumulation in hepatoma cells, which can be reduced by 2-bromopalmitate.

This study uses phylogenetic analysis to infer the transoceanic dispersal history and foraging evolution of Kalotermitidae termites, finding that dispersal and human activity shaped their global distribution.

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

This paper reports the structure and function of Pseudomonas aeruginosa CtpA, showing it forms an inactive hexamer that requires the spiral-shaped lipoprotein LbcA for activation and substrate delivery.

This paper reviews selenium content in wheat farming soil, grain, and derived foods globally, showing how agronomic practices can enhance selenium levels in wheat and its products.

This study shows that anti-aggregation strategies in microbial space colonization enhance competitive success by increasing Space Accessibility, offsetting lower growth rates or initial abundance.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

The paper compares the tumor-repressing effects of TCF11 and Nrf1, showing TCF11 is more potent, while both have similar regulatory profiles distinct from Nrf2.

This study assesses batch effects in TMA-based cancer biomarker studies and shows mitigation methods reduce variance and alter clinical associations.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This study identifies Tcfl5 as a testis-specific protein essential for male fertility, showing that heterozygous mice are infertile and exhibit abnormalities in spermatids and spermatozoa.

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

The paper reports crystal and cryo-EM structures of human CCKAR and CCKBR with ligands, revealing ligand recognition and activation mechanisms.

This study tracks long-term persistence of CD4+ CAR T-cells in CLL patients, showing their role in sustained remission and clonal stability over 10 years.