S. Kumar

This study shows that hemangiosarcoma cells create a microenvironment that supports hematopoietic expansion, resembling bone marrow niche cells.

The paper identifies differential antiviral effects of IFN-alpha subtypes against SARS-CoV-2 and highlights IFN5's superior activity, suggesting therapeutic potential.

This study identifies lapatinib, an ErbB inhibitor, as a broad-spectrum antiviral that suppresses SARS-CoV-2 and VEEV replication, inflammation, and lung injury through ErbB-mediated mechanisms.

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

This study identifies that withaferin A inhibits T-cell motility by targeting ZAP70 and cytoskeletal pathways, offering potential for immune response modulation.

The paper shows that JG-98, an Hsp70 inhibitor, causes cell death by activating the eIF2α phosphorylation pathway through the Hsp70-Bag3 complex, linking ER and cytoplasmic proteotoxicity.

This study optimizes the production of rec-BSP1 and demonstrates its ability to enhance buffalo sperm motility and blastocyst production in vitro.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

This study integrates cancer cell phylogeny with mutational signature deconvolution to track mutational process changes in lung cancer patients over time.

This paper introduces a data-driven birth-death tree prior to improve Bayesian node age estimates in calibration-poor phylogenies, reducing the need for many well-constrained calibrations.

This study compares the transmission efficiency of SARS-CoV-2 UK variant and D614G variant in Syrian hamsters via different routes, finding comparable transmission between the two variants.

The paper shows that prion-like domain-containing endocytic coat proteins form viscoelastic condensates that enable actin-independent membrane remodeling and endocytosis in yeast.

This study identifies DPYD as a regulator of hepatic steatosis through in vitro experiments showing its inhibition reduces lipid accumulation and its gain-of-function mutation increases lipid burden.

This study investigates how succinimide formation in an archaeal glutaminase enhances thermostability through structural and computational analysis.

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

The paper shows that negative DNA supercoiling reduces stochasticity in protein-mediated DNA looping, making it deterministic and ergodic within bacterial doubling time.

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

This study evaluates the immunogenic potential of the DNA vaccine ZyCoV-D against SARS-CoV-2 in animal models, showing antibody and Th-1 responses.

This study assesses diurnal raptor richness and diversity across different land uses in Jammu Shiwaliks, finding higher abundance in farmlands and lower diversity overall.

The paper shows that systemic inflammation triggers rapid migration of specific myeloid progenitors from bone marrow to lymphatics via Ccl19/Ccr7, promoting anti-inflammatory responses and replenishment of lymph node dendritic cells.

This study identifies Osa-miR820 as a regulator of OsDRM2 that enhances salt stress tolerance in rice with agronomic benefits.

This paper identifies molecular mechanisms of attenuation in the SA14-14-2 Japanese encephalitis vaccine strain, showing loss of NS1 and envelope protein folding defects lead to enhanced immune responses.

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

This study identifies temperature-regulated genes in Stenotrophomonas maltophilia using transcriptome analysis, revealing adaptations for human body temperature.

This study identifies host proteins interacting with SARS-CoV-2 5' and 3' UTRs, revealing Lamp2a's antiviral role by reducing viral RNA levels.

The paper develops a mathematical model of the AMPK-Akt feedback loop, showing it can generate multistability and phenotypic switching in cancer cells, supported by experimental and clinical data.

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

This study shows that HIV-1 RNA's m6A modifications suppress type-I interferon induction in monocytic cells by evading RIG-I sensing.