W. Wang

This study traces the evolutionary origin of the Hippo pathway from unicellular ancestors and examines its oncogenic alterations in mammals.

This paper introduces a transcriptome analysis workflow to study drug-drug interactions, using Compound Kushen Injection and chemotherapy drugs as a proof of principle, identifying MYD88 as a key regulator.

This study shows that cutaneous lymphoma subclones evolve independently in different skin microenvironments, leading to ecological heterogeneity and intratumoral heterogeneity.

This study shows that Aurora-B phosphorylates SAF-A to remove RNA from chromosomes during prophase, preventing anaphase segregation errors.

The paper uses molecular dynamics simulations to study how cleavage of SAA protein affects its down-regulation and aggregation potential, proposing a mechanism involving conformational switching and environmental conditions.

This study examines how substrate stiffness affects human umbilical vein endothelial cell behavior, finding increased CX40 and GAG content and decreased actin stress fibers and proliferation on stiff substrates.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study identifies convergent genomic signatures of high altitude adaptation in domestic mammals by analyzing 327 genomes, revealing positive selection in genes like EPAS1 and C10orf67.

The paper analyzes gene expression dynamics in C. elegans to show rapid molecular evolution in genes with declining transcript abundance during early embryogenesis, challenging existing evolutionary models of development.

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

This study identifies multiple neoplastic T-cell clones in MF lesions and peripheral blood, suggesting they continuously replenish lesions and contribute to tumor heterogeneity.

This study identifies the TDP1/TOP1 activity ratio as a predictive indicator for GBM susceptibility to irinotecan, suggesting TDP1 inhibition could enhance treatment efficacy.

The paper introduces Cp-hap, a method to detect chloroplast structural haplotypes using long-read sequencing, revealing two widespread haplotypes in most land plants.

The paper identifies a novel plant-specific TRAPP complex component, TRIPP, and shows its role in plant development through proteomic and genetic analyses in Arabidopsis.

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

This paper introduces a drug combination sensitivity score (CSS) to efficiently evaluate drug synergy in cancer, showing high reproducibility and predictive accuracy.

This study identifies USP7's dual role in stabilizing EZH2 and facilitating PRC2 chromatin loading, promoting melanoma progression and correlating with poor patient prognosis.

This paper shows how different ERK2 inhibitors shift conformational states by exploiting activation loop dynamics, affecting dephosphorylation rates.

DrugComb provides an open-access portal for drug combination screening data, enabling analysis and prediction of drug synergy using linear regression and chemical fingerprints.

This study evaluates the effects of insecticides on DNA methylation during early mouse embryonic stem cell differentiation and identifies imidacloprid's potential developmental impact through altered methylation patterns.

The paper investigates the molecular forces driving reentrant liquid condensation in RNP-RNA complexes, showing how short-range attractions and long-range repulsions control phase transitions.

This study uses transcriptome analysis to investigate how two herbal extracts in Compound Kushen Injection interact, showing Kushen drives cytotoxicity and Baituling enhances it while activating immune pathways.

The paper analyzes global variability in IgG glycosylation across populations, finding that country of residence and socioeconomic development strongly influence glycan features and monogalactosylation levels.

This study investigates how molecular crowding affects the physical properties of RNP condensates, showing they transition from liquid to gel-like states and that this is independent of LCD charge patterns.

This study identifies candidate molecular mechanisms of Compound Kushen Injection by analyzing transcriptome changes in cancer cells and linking them to gene expression and pathway alterations.

The paper describes a modified TCA/acetone precipitation method for plant protein extraction that is faster and reduces protein degradation compared to traditional methods.

This study investigates the antimycobacterial mechanism of FP-11g, a fluoroquinophenoxazine compound, and identifies resistance mechanisms in Mycobacterium smegmatis.

This study identifies and analyzes microbial contaminants in biological laboratories, finding that lab type influences microbial communities more than sampling site, and identifies environmental and human factors as key sources.

This study identifies molecular mechanisms governing integrin αVβ5 clustering in flat clathrin lattices in human keratinocytes, showing dependence on vitronectin, calcium, and adaptor proteins.

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.