Y. Luo

The paper expands a current-flow betweenness method to study protein-protein allosteric regulation by analyzing mutations at the ALK2-FKBP12 interface.

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

The paper describes the UCSC Xena platform, which enables secure visualization and analysis of both public and private cancer genomics data through web-based tools and hubs.

The paper identifies a genomic region Lyb-2-4 associated with hypervirulence in carbapenem-resistant Acinetobacter baumannii, showing higher mortality in infected patients and mice.

This study identifies ISLR as a stromal factor that suppresses epithelial Hippo signaling to promote intestinal regeneration and cancer.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

This paper evaluates the biocontrol potential of PGPR strain Ba168 against tobacco black shank caused by Phytophthora nicotianae, showing it is effective but slightly less than a chemical mixture.

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

This study uses mathematical models to investigate how de-differentiation can be an adaptive mechanism in cellular hierarchies, deriving thresholds for its emergence based on hierarchy properties and de-differentiation patterns.

This paper introduces a method to robustly determine protein allosteric signaling pathways using current-flow betweenness analysis of MD simulations.

This paper develops a platform to multiplex profile single-cell EV secretion, revealing heterogeneity in EV phenotypes and secretion patterns in OSCC cells.

This study identifies a Ras-MAPK signaling pathway activated by SV40 during late infection that drives vacuolization, cell lysis, and virus release.

The paper describes a new standing rest behavior in Tibetan antelopes called 'Puppet behavior,' observed more frequently in males and linked to thermoregulation and anti-predation.

This study shows that exogenous calcium ions increase Saccharomyces cerevisiae cell wall thickness and patulin adsorption by enhancing key enzyme activities.

The paper examines factors influencing gut microbiota density across mammals, disease states, and interventions, finding host and microbial factors shape density and impact health.

This study evaluates FMT efficacy in CDI patients with and without IBD, finding no difference in recurrence rates and showing engraftment depends on IBD treatment, not disease severity.

This study shows SlARF10 regulates chlorophyll and sugar accumulation in tomato fruits by controlling starch synthesis and photosynthesis.

This study identifies novel interactions of MAD1 domains with MAD2 conformers and their regulation by MPS1 kinase, revealing mechanisms for mitotic checkpoint signaling.

This paper identifies a conserved electrostatic lock in STKR1 kinases that regulates kinase activity through a salt-bridge, showing how phosphorylation, FKBP12 dissociation, and mutations disrupt this lock to cause leaky signaling.

The paper identifies the minimal region of Piezo1 responsible for Yoda1 binding and shows that asymmetric binding to a single subunit is sufficient for channel activation.

The paper identifies novel antimicrobial peptides from the rumen microbiome and demonstrates their efficacy against MRSA in vitro and in a mouse model.