Y. Qi

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

This study identifies 309 host proteins interacting with SARS-CoV-2 RNA during infection and reveals their roles in virus-induced cell death and mitochondrial dysfunction.

The paper analyzes proteome and phosphoproteome changes in EGFR TKI-resistant lung cancer cells to identify drug targets that can overcome resistance.

The paper introduces a data-driven polymer model to study diploid genome organization, validated against Hi-C data and showing chromosome positioning principles.

This study identifies a novel role for sphingosine kinase 2 in the metabolism of sphinga-4,14-diene lipids, showing that its absence leads to their accumulation in the brain due to slower catabolism.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

The paper develops a discrete dynamic model for human epidemics and identifies key parameters influencing total cumulative cases through sensitivity analysis.

This study shows that temporarily stopping CAR-T cell signaling can reverse exhaustion and improve their anti-tumor function through transcriptional and epigenetic changes.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

The paper uses a variational autoencoder to analyze chromatin structure fluctuations and identifies a reaction coordinate for chromatin folding, revealing insights into TAD formation and folding energetics.

The paper identifies MRISC cells as a novel intestinal stem cell niche that produces R-spondin1 via Map3k2 signaling to promote intestinal regeneration after damage.

This study uses CFD simulations to analyze how oral appliances alter upper airway morphology and airflow dynamics in OSAHS patients, showing reduced resistance and improved patency.

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

The paper investigates S. aureus colonization and infection in Chinese NICU neonates, identifying common clones and risk factors for colonization.

The paper develops and validates quantitative imaging protocols for preclinical tumor burden assessment in a co-clinical trial using multimodal small animal imaging.

The paper introduces a method to visualize and analyze correlated interdomain motions using continuous conformational distributions, applied to study staphylococcal protein A's binding thermodynamics.

This paper introduces a computational model that predicts 3D chromatin organization from 1D genomic data, showing agreement with experimental measurements.

This study shows clonal bacterial populations can exhibit metabolic specialization through dynamic state-switching to manage overflow metabolites like acetate.