F. Wang

The paper shows that H3K27me3 chromatin state changes are critical for terminal differentiation in human hematopoiesis, being retained in lymphoid cells but lost in monocytes and erythroblasts.

The paper describes electron microscopy of KHV GY01 infected cells and whole genome analysis to study its characteristics and phylogenetic relationships with other KHV strains.

This study identifies YTHDF1 as a key regulator of intestinal immune responses against bacterial infection by modulating TRAF6 mRNA translation through m6A methylation.

This study engineers Yarrowia lipolytica to produce squalene by optimizing the mevalonate pathway, achieving a 28-fold increase in squalene yield.

This study systematically analyzes ferroptosis in cancer using TCGA data, finding that ferroptosis-related genes are aberrantly expressed and that FPI is associated with prognosis and drug sensitivity.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

The paper shows that inhibiting the integrin-TGF-β axis enhances NK cell function against glioblastoma stem cells, suggesting it as a therapeutic target.

NAD+ supplementation enhances T cell activation and tumor-killing capacity in immunotherapies.

This study shows that keratins K6 and K16 regulate mitochondrial structure, function, and dynamics in keratinocytes, contributing to oxidative stress in pachyonychia congenita.

This study investigates the role of reactive oxygen species (ROS) in plant cell division and cold stress adaptation, finding that ROS influence cell wall stiffness and regulate division rates in Brassica napus.

TipQAD quantifies spatiotemporal fluorescence dynamics in tip-growing cells, providing accurate measurements of FP-labeled proteins in cytoplasm and plasma membrane.

This study profiles single-cell epigenomic and transcriptomic data from Parkinson's disease mouse brain to identify early biomarkers and cellular contributions to disease pathology.

This study shows UVR8 mediates UV-B and UV-A responses in Arabidopsis, with CRYs required for longer UV-A wavelengths, and highlights the need for plant-specific UV waveband definitions.

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

This study uses internet search data to show seasonal variation in cancer recurrence queries, with peaks in early summer (northern hemisphere) and late summer (southern hemisphere).

The paper shows that ATPase binding at one end of the 20S proteasome allosterically opens the opposite gate, promoting symmetric and asymmetric proteasome configurations.

This study shows SPOP promotes ubiquitination and degradation of MyD88, suppressing innate immune responses and reducing susceptibility to Salmonella typhimurium infection.

This study shows BMP9 induces osteogenic differentiation in GC-1spg cells through upregulated markers and in vivo bone formation.

This paper introduces amino and PEG-amino functionalized graphene oxide grids to improve sample concentration, distribution, and protection for cryo-EM.

The paper reanalyzes experimental data to show that action potential propagation delays are small compared to signal duration, suggesting a new physical model for neural signal communication.

This study improves the specificity of adenine base editor ABE7.10 by replacing SpCas9 with high-fidelity Cas9 variants, showing reduced off-target activity in four test sites.

This study identifies molecular and cellular differences between murine syngeneic tumor models and human tumors, highlighting limitations in using syngeneic models for immunotherapy research.

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.

This paper develops rice tissue media to enhance conidiation of Ustilaginoidea virens, improving pathogenicity testing and genetic analysis for false smut resistance.

The paper compares transcriptome profiles of maize CSSLs I178 and X178 under accelerated ageing to identify genes and alternative splicing events associated with seed longevity.

GEAN improves gene structure annotation lift over from a reference genome to newly sequenced individuals by addressing alignment inconsistencies through a weighted dynamic programming algorithm.

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

The paper identifies urine-enriched RNAs and metabolites in prostate cancer patients and normal individuals, revealing altered glutamate metabolism and TCA cycle in cancer cells.