F. Wang

The paper shows that in fatal ARDS, alveolar type 1 cells do not fully differentiate from transitional cells without fibrosis, leading to persistent barrier permeability and respiratory failure.

This study develops process-based tree phenology models for subtropical trees using experimental data, showing advanced spring phenology under warming with species-specific responses.

This study shows that increased flavonol accumulation in tomato hp2 mutant pollen enhances thermotolerance and reproductive success under heat stress.

This study shows that CSNK1G2 inhibits RIP3-mediated necroptosis, reducing testis aging in mice and conserved in humans.

This study identifies SARS-CoV-2 ORF3 as an inducer of ERphagy, leading to ER stress and inflammatory responses, which may be targeted for COVID-19 treatment.

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

The paper uses molecular and morphological data to clarify species boundaries in Betula section Costatae, identifying a new species, Betula buggsii, within the group.

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

The paper tests hypotheses about genetic diversity patterns in Betula albosinensis, finding support for the central-marginal hypothesis and the role of multiple glacial refugia.

The paper investigates the spatial and vertical distribution of microbial communities in methane-rich sediments of Saco do Mamangua, Brazil, highlighting the prevalence of Bathyarchaeota.

This study shows that SARS-CoV-2 spike protein induces inflammation and epithelial damage, which can be reduced by an antagonistic peptide and FDA-approved drugs.

This study uses molecular dynamics simulations to investigate how mutations affect nisin solubility and evaluates force fields' ability to model solubility of uncommon amino acids.

This study uses single-cell RNA-sequencing to analyze decidual and peripheral leukocytes in normal and RSA pregnancies, revealing immune dysregulation in RSA.

This study infers SARS-CoV-2 epitopes recognized by TCRs through structural modeling and designs a T cell-based vaccine using immunoinformatics tools.

This paper develops covalently linked graphene oxide affinity grids for cryo-EM, enabling high-resolution reconstructions by preventing particle denaturation and aggregation.

The paper identifies how RDR2 binds to the clamp domain of Pol IV to facilitate dsRNA synthesis for siRNA production in plants.

This study identifies PFKM as a direct target of celastrol, showing that its inhibition promotes weight loss and leptin sensitivity through AMPK/ACC signaling.

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

The paper analyzes multiomics data to show that uncoupling of copy number and gene expression (UCNE) in cancer is associated with oncogenic signaling and immune suppression, and identifies potential therapeutic targets.

This study identifies NSP8 as a SARS-CoV-2 protein that suppresses MDA5-mediated antiviral immune responses by inhibiting type I IFN signaling.

The paper analyzes the airway microbiome in COPD patients at species and strain levels, revealing intra-genus diversity linked to inflammatory phenotypes and clinical outcomes.

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

The paper assesses how tumor PD-L1 levels impact TCR-T cell function and anti-PD-(L)1 efficacy using single-cell RNA sequencing and cellular assays.

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.