H. Guo

This study determines the structure of mycobacterial ATP synthase with and without bedaquiline, revealing how the drug binds and induces conformational changes to inhibit ATP hydrolysis.

This study identifies 23 SARS-CoV-2 3CLpro inhibitors through high-throughput screening, with several showing potent activity against viral infection.

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

This study identifies synergistic and antagonistic drug combinations against SARS-CoV-2 in vitro using in silico prioritization and experimental testing.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

This study identifies nucleolin as essential for RHDV replication by facilitating the formation of replication complexes through interactions with viral proteins.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

The paper introduces EER data format for cryoEM DDD movies, preserving spatial and temporal resolution without increasing file size.

The paper identifies allelic differences in terpene synthase genes that contribute to correlated variation in herbivory-induced and floral volatiles in wild tobacco.

This paper introduces an ultrasensitive fluorogenic probe for detecting human heparanase activity with a picomolar detection limit and demonstrates its use in high-throughput inhibitor screening.

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

This study identifies TPX2 activation by GM130 on mitotic Golgi membranes as critical for astral microtubule formation and spindle orientation.

The paper analyzes 120 SARS-CoV-2 genomes to identify genetic subgroups, recombination events, and a unique spike protein insertion that may enhance infectivity.

The paper develops a robust ChIP protocol that significantly improves enrichment fold in birch and Arabidopsis, and is applicable to both woody and herbaceous plants.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study identifies two distinct bacterial biofilm components that induce metamorphosis in Hydractinia echinata larvae, showing their combined activity enhances transformation rates.

The paper introduces a simple ultrasonic cryo-EM specimen preparation device that improves sample transfer efficiency and reduces air-water interface interactions.

This study identifies mycofactocin (MFT) as a redox cofactor in Mycolicibacterium smegmatis, reveals its oligoglycosylation by MftF, and confirms its role in ethanol metabolism.

RhizoVision Crown is an open-source platform for high-throughput root crown phenotyping in crops, validated with simulated images and used on soybean and wheat, showing species-specific heritability.

This study identifies the genetic basis for the evolution of a novel floral scent in wild tobacco, showing how gene expression changes lead to adaptive volatile compound production.

The paper identifies novel F420 derivatives in Paraburkholderia rhizoxinica, reveals their biosynthesis pathway, and demonstrates their functional activity and potential for biocatalysis.

This study shows that maize with reduced nodal roots reallocates biomass to lateral and early-emerging axial roots, enhancing nitrate foraging efficiency under low nitrogen conditions.

The paper quantifies cell wall mechanics in fission yeast to show how wall stiffness scales with cell diameter and adapts to size changes.

SpitWorm, a robotic device, mimics insect herbivory by causing mechanical wounding and applying salivary components, inducing plant defense responses similar to real larvae feeding.

The paper determines the structure of a bacterial ATP synthase using cryo-EM, revealing its mechanism and how it performs core functions similar to mitochondrial complexes.

The paper develops IPTG-controlled conditional suicide plasmids for efficient and regulatable transposon mutagenesis in multiple bacterial species.