H. Guo

This study shows that heat-acclimated mice have more Tregs, which reduce inflammation and improve heat tolerance through the PD-1/PD-L1 pathway.

This study shows that phosphorylation of DSB-1 by PP4PPH-4.1 and ATRATL-1 regulates meiotic DSB levels in C. elegans, with DSB-2 compensating for age-related inactivation of DSB-1.

The paper develops and validates a series of assays to identify TMPRSS2 inhibitors as potential COVID-19 treatments, identifying six compounds with varying clinical statuses.

The paper uses cryoEM to study yeast mitochondrial ATP synthase under strain during ATP-hydrolysis-driven rotation, revealing structural deformation of the peripheral stalk and its role in opposing bending forces.

A human antibody, VacW-209, broadly neutralizes SARS-CoV-2 variants including Omicron by targeting a conserved epitope, highlighting the importance of such antibodies in pandemic control.

This study investigates the substrate specificity of human SETD3, showing it can methylate histidine and its mimics, with histidine being the most efficient substrate.

A third dose of inactivated SARS-CoV-2 vaccine significantly enhances plasma neutralization and generates high-affinity anti-RBD memory B cells against variants like Beta, Delta, and Lambda.

This paper develops a high throughput screening assay using SARS-CoV-2 pseudotyped particles to identify inhibitors of viral entry, finding 7 active compounds effective against both pseudotyped particles and live virus.

This study shows hypertension in non-human primates leads to gut barrier dysfunction and microbial translocation, altering the gut microbiome.

This study identifies RNA aptamers secreted by Gram-positive bacteria that activate the STING pathway to induce IL-1β release in human macrophages.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

The paper investigates how gravitation stress affects the transmembrane potential in toad bladder urothelium, showing increased chloride channel activity and altered ion permeability.

This study identifies the mitochondrial ATP synthase as the target of apoptolidin family glycomacrolides and demonstrates their efficacy in suppressing leukemia progression.

The paper identifies a novel lineage of SARS-related coronaviruses from bats that use bat ACE2 receptor but not human ACE2, suggesting potential zoonotic risks.

This study identifies TbFUT1 as an essential mitochondrial fucosyltransferase in Trypanosoma brucei, critical for both bloodstream and procyclic forms and potentially therapeutically relevant across trypanosomatids.

This paper identifies FUT1 as an essential fucosyltransferase in Leishmania, localized to mitochondria, with enzymatic activity required for viability and mitochondrial function.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

RhizoVision Explorer is an open-source software for root image analysis that provides accurate measurements and batch processing, validated against ground truth data and compared to existing tools.

This study reports the crystal structure of gp16-CTD and simulations of the full-length gp16, revealing its role in dsDNA packaging through interactions with pRNA and dynamic domain interplay, refining the inchworm-revolution model.

This study examines root trait interactions and deep nitrate capture in switchgrass ecotypes under water and nitrogen stress, finding shared and distinct responses and a link between deep rooting and aboveground growth.

This study identifies crosstalk between brassinosteroid and TORC signaling in Arabidopsis through multi-omics analysis of mutants, revealing shared gene-products and a kinase signaling network.

This study shows that PEBP4 interacts with TYLCV CP to regulate apoptosis and autophagy in whiteflies, balancing virus loading and immune response.

This study identifies the ZmCd1 gene controlling cadmium accumulation in maize grains and develops molecular markers for breeding low-Cd maize varieties.

This paper demonstrates that iRGD-liposomes enhance the delivery and efficacy of AR-ASO in treating prostate cancer and bone metastasis without increasing toxicity.

This study identifies the structural and molecular mechanisms of two neutralizing antibodies against FMDV, showing they disrupt virus-receptor interactions and provide prophylactic and therapeutic benefits.

The paper introduces a high-throughput phenotyping platform to measure multiple ion uptake rates in maize roots, revealing shared genetic mechanisms and heritable variation in nutrient uptake.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

The paper combines functional phenomics and root economics theory to analyze root traits in winter wheat, identifying genetic regions and traits linked to root efficiency for sustainable breeding.

This study shows that evolutionary arms race between bat SARSr-CoV spike proteins and ACE2 drives genetic diversity, with SARSr-CoV spike proteins showing higher binding affinity to human ACE2 than bat ACE2.