J. Wang

The study tracks vagino-cervical microbiome changes in 60 women over a year after oral probiotics, finding no colonization but stability in Lactobacillus-dominated communities and potential benefits for some individuals.

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

The paper screens SARS-CoV-2 target cells across 11 animal species using single-cell transcriptomes, finding higher proportions in cats and detecting them in multiple pig cell types.

This study presents MKK7 crystal structures and identifies new allosteric targets, revealing structural mechanisms of activation and potential drug candidates.

This study identifies a molecular pathway by which enteroendocrine cells respond to bacterial tryptophan catabolites, activating enteric and vagal neurons through Trpa1 signaling.

The paper screens endophytic bacteria from Taxus chinensis for IAA and lipopeptide production, identifies non-toxic strains, and suggests their potential for biofertilizer use.

This study shows that Th17 cells contribute to resistance to MEK inhibitor and anti-PD-L1 therapy in KRAS/p53 mutant lung cancers and suggests a triple combinatorial therapy to overcome resistance.

This study evaluates wheat phenology prediction models in Australia, finding that multi-model averaging performs nearly as well as the best single model, with an average error of 9 days.

This study shows cancer cells use fructose metabolism to drive the Warburg effect by converting glucose to fructose via polyol pathways and exporting fructose to the tumor microenvironment.

This study identifies integrin β3 as a RACK1-interacting protein essential for PRRSV infection and NF-κB activation in Marc-145 cells, revealing a positive feedback loop involving NF-κB and ITGB3/RACK1.

The paper determines the cryoEM structure of a long-lived translation initiation intermediate involving eIF5B, Met-tRNAiMet, and the ribosome post GTP hydrolysis.

BCM3D improves segmentation and classification of bacterial cells in 3D biofilms using deep learning and mathematical analysis.

This study identifies ABCF1 as a coactivator for OCT4/SOX2 that links transcription with DNA damage sensing to maintain stem cell pluripotency and genome integrity.

The paper investigates how SARS-CoV-2 infection induces epithelial-mesenchymal transition (EMT) in lung cancer models, leading to changes in gene expression and potential therapeutic targets.

This study shows that reconstitution and storage conditions of trypsins can significantly affect nonspecific cleavages in tryptic digestion, with mildly acidic conditions promoting up to 20% nonspecific activity.

The paper examines how aging affects brain network integration during working memory tasks, finding that older adults show increased network integration with higher task difficulty and WM capacity.

The paper uses CRISPR/Cas9 to study alkaline phosphatase isoforms and their regulatory network in diatoms, revealing their functional differences and compensatory roles in phosphorus scavenging.

The paper identifies lipid droplets in multiple bacterial phyla, shows their conservation and inheritance, and estimates their origin to 3.19 billion years ago.

The paper identifies a singleton NLR gene, DM10, and its interaction with DM11 causing hybrid necrosis in Arabidopsis thaliana.

This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.

This study uses genetic analysis to trace the origin and migration history of the plant pathogen Phytophthora palmivora, identifying Southeast Asia as its center of diversity and a single colonization event responsible for its global spread.

This paper develops a CRISPR-based DNA detection method (CADD) that rapidly and specifically detects DNA from bacteria, cancer cells, and viruses in 30 minutes at room temperature.

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

This study uses chemoinformatics to engineer polyketide synthases for producing saturated β-carbon compounds, finding a correlation between chemical similarity and product titers.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study introduces the M. tuberculosis-specific gene pair into M. kansasii to model pathoevolution, finding that 1-TbAd production enhances early infection but impairs long-term survival.

This study establishes a BRBV replicon system and identifies myricetin as a potent inhibitor of BRBV replication with a high therapeutic index.

The study identifies microbial communities associated with ECM Russula symbiosis and sporocarp production in Fagaceae plants in southern China.

This study identifies PKD-2-carrying ciliary EVs as mechanoresponsive and directionally transferred in C. elegans, suggesting conserved mechanisms across species.