K. Chen

This study determines the crystal and cryoEM structures of ALC1 and its nucleosome-bound form, revealing the autoinhibition mechanism and activation by the nucleosome.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study identifies two molecular subtypes of gastric cancer using multi-omics data and clustering algorithms, showing distinct survival outcomes and therapeutic responses.

The paper shows that autocrine TNF-α/TNFRI signaling drives CD4+ T cell lymphopenia and dysfunction in severe COVID-19, and TNF-α blockade improves outcomes.

This study identifies ST365 as the predominant causative agent of S. Weltevreden diarrhea outbreaks globally and discovers a novel virulence plasmid associated with its pathogenicity.

This paper introduces excitation spectral microscopy to enable high multiplexing of fluorescent targets in live cells with low crosstalk and high temporal resolution.

This study reveals high intratumoral heterogeneity in pancreatic cancer cell lines and highlights issues with reproducibility and validity of preclinical models.

This study identifies a tubular ERGIC (t-ERGIC) formed by SURF4 that enhances ER-to-Golgi transport of specific cargoes through unique structural and functional properties.

This paper introduces a bifocal parallax single particle tracking method to study 3D rotational and translational motion of cargo in living cells, revealing new interactions at microtubule intersections.

The study identifies how precursor chain length, plant genotype, and spatio-temporal gradients influence product-precursor ratios in the cuticular hydrocarbon-producing pathway of maize silks.

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

This study improves timing accuracy in single-cell cancer evolution by modeling errors in single-cell DNA sequencing data using BEAST2, showing that error accounting shifts divergence times forward and reduces overestimation of phylogenetic diversity.

This study examines how arbuscular mycorrhizal fungi, insect pollination, and nutrient availability interact to affect raspberry yield, finding additive and synergistic effects.

The paper shows that vitamin D-activated Trem2+ macrophages promote angiogenesis and reduce fibrosis, offering a new strategy for advanced cell therapies in complex wounds.

The paper shows that RIPK1 activates GSDME in neutrophils to promote anti-Yersinia defence through pyroptosis and IL-1β release.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

This study identifies divergent molecular signatures of regeneration and fibrosis during wound repair using multimodal analysis.

This paper demonstrates copying and random access of 3D DNA structural barcodes using modified PCR and nanopore measurements.

This study investigates how the intracellular localization of Mycobacterium tuberculosis affects the efficacy of the antibiotic pyrazinamide (PZA) using multimodal microscopy techniques.

This study combines DXA and Raman spectroscopy to predict femoral fracture toughness in mice, showing improved accuracy with integrated data.

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.

This paper introduces a hierarchical 3D-motion learning framework to map animal spontaneous behavior by capturing kinematics and learning dynamic behavior patterns.

The paper analyzes multiomics data to show that uncoupling of copy number and gene expression (UCNE) in cancer is associated with oncogenic signaling and immune suppression, and identifies potential therapeutic targets.

This paper develops a nanobody platform for drug delivery, showing improved pharmacokinetics and therapeutic efficacy of NbHSA conjugates.

The paper uses single-molecule and super-resolution microscopy to map nanoscale diffusional heterogeneities in live mammalian cell membranes, revealing differences in diffusivity across membrane regions and identifying protein crowding as a potential cause.

This study shows CRAMP is required for macrophages to eliminate phagocytosed E. coli via autophagy, involving ATG5, LC3-II, and LAMP-1.

The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.

This study identifies potent human neutralizing antibodies against SARS-CoV-2 from convalescent patients, with some showing high efficacy in blocking viral entry.

The paper designs peptides based on SARS-CoV-2 spike protein HR1/HR2 domains to inhibit viral fusion and entry into host cells, showing they can form complexes with HR1 peptides.

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.