K. Chen

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

The paper reports the cryoEM structure of the ISW1a complex bound to the dinucleosome, revealing its mechanism of nucleosome spacing and organization.

This study identifies androgen-mediated TGFβ expression as a mechanism suppressing anti-tumor neutrophil response in bone metastatic prostate cancer and shows that combining ADT with TGFβ receptor inhibition restores neutrophil cytotoxicity.

This paper develops a high-throughput bronchosphere model for COPD and screens compounds to identify those that reverse CSE-induced phenotypic changes.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

This study identifies and characterizes circRNAs in moso bamboo, their biogenesis, function, and response to gibberellins and auxins.

This paper introduces a method to control single-molecule translocations through a nanopore with spatial and temporal precision, achieving high-resolution DNA analysis.

This paper improves CRISPR-Cas12a genome editing by combining rational engineering and directed evolution to enhance homology-directed repair efficiency.

The paper identifies a four-gene signature associated with EV secretion in breast cancer and links it to poor prognosis and immune evasion.

The paper defines cancer epithelial and immune cell heterogeneity in breast tumors using single-cell RNA-seq and develops a tool to predict anti-PD-1 therapy response.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

This study uses two-photon microscopy to observe astrocyte reactivity in mouse brains after intracortical microelectrode implantation, revealing distinct spatiotemporal dynamics compared to other glial cells.

The paper examines how pollinators and seed predators influence selection on floral stalk height in Pulsatilla alpina, finding disruptive selection and positive effects on reproductive success.

This paper develops a scalable method to create dense single-molecule protein arrays using DNA origami and surface functionalization, enabling high-sensitivity proteomic analysis.

This study identifies Slc37a2 as a sugar transporter in osteoclast secretory lysosomes, showing its role in bone metabolism through dynamic tubular networks and its impact on bone mass.

The paper introduces a modular, mass-produced tissue chip platform for barrier tissue models, validated for blood-brain barrier studies and reconfigurable for other applications.

This study uses CRISPR/Cas9 to knockout Ndrg2 in dendritic cells, enhancing their regenerative capacity for wound healing in mouse models.

This study analyzes neoantigen burden in breast cancer patients using whole-exome and RNA sequencing, finding high patient-specificity and correlation with somatic mutations.

This study uses single-cell and bulk RNA sequencing to identify cellular changes and interactions in necrotizing enterocolitis, highlighting inflammatory macrophages, T cells, and epithelial-mesenchymal-immune interactions.

The paper investigates reduced antigenicity of the Omicron variant, showing it evades antibodies and lowers serologic response, with implications for vaccine development.

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

The paper shows allometric tissue-scale forces drive pathological foreign body response by activating Rac2 signaling in immune cells, independent of implant properties.

This study shows STEAP1 can support a cross-membrane electron transfer chain via FAD, and determines the structure of STEAP2 in complex with NADP+ and FAD.

This study shows CD32A-chimeric receptor T cells can identify CD32A ligands, predict breast cancer sensitivity, and improve prognosis without antibodies.

The paper reports the structure and function of PurTCp, a NAT family transporter from Colwellia psychrerythraea, showing it transports purines via H+-dependent mechanism and identifies a critical aspartate residue.

This study shows that Regnase-1 deficiency increases resistance to Klebsiella pneumoniae infection by enhancing Type I interferon responses, despite not affecting bacterial clearance or pro-inflammatory cytokine expression.

This study identifies Prevotella histicola as a protective agent against estrogen-deficiency induced bone loss via the gut microbiota-bone axis in mice.

This study shows spermidine directly inhibits Th17 cytokine production via PRDX1-dependent antioxidant activity, reducing lung inflammation in mouse models.

This study shows that removing PU.1 in adipocytes increases energy expenditure and improves metabolic syndrome in aging mice.