M. Lee

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

This study identifies Dehalobium species in Sydney Harbour Estuary sediments capable of dechlorinating 2,3,7,8-tetrachlorodibenzo-p-dioxin, showing their role in reducing PCDD/F toxicity in marine environments.

This study investigates how salt stress affects oil palm by analyzing gene expression and stomatal development, finding that EgSPCH promotes stomatal increase which aids in salt tolerance.

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

The paper introduces a method to determine DNA-protein binding states using diffusivity contrast and validates it with PIFE, enabling simultaneous mapping of stoichiometry and binding location.

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.

This paper identifies a novel class of TMPRSS2 inhibitors that effectively block SARS-CoV-2 and MERS-CoV entry and show promise as a therapeutic for COVID-19.

This study uses AcePET to visualize tumor boundaries and reactive astrocytes in GBM, showing that targeting MCT1 improves survival by enabling complete resection of cancer stem cells.

This study shows CCL28 enhances neutrophil responses in mucosal infections, improving pathogen clearance in some cases but worsening disease in others.

This study identifies multiple SARS-CoV-2 spike protein sites susceptible to cleavage by cathepsins B, K, L, S, and V using computational and experimental methods.

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

The paper analyzes HIV nucleic acids in cellular conjugates from peripheral blood to understand HIV reservoirs and their characteristics in different patient groups.

This study shows STING agonists reduce cancer pain and bone destruction in mouse models by modulating neurons, immune cells, and osteoclasts.

This study characterizes the structure, conformation, and glycosylation of the SARS-CoV-2 spike protein expressed by the ChAdOx1 nCoV-19/AZD1222 vaccine, confirming its native-like properties.

This study identifies potent SARS-CoV-2 neutralizing antibodies targeting the N-terminal domain (NTD) and reveals they bind a common supersite on the spike protein.

The paper uses optical diffraction tomography to image and analyze 3D vasculogenesis in vitro without exogenous labeling.

The paper assesses how different microbial consortia affect phosphorus solubilization and plant growth, finding that combined species outperform individual species.

The paper expands the human gut microbiome reference database by incorporating newly assembled genomes from under-represented Asian populations, improving taxonomic and functional classification and revealing associations with autoimmunity.

This study investigates leaf mold incidence in tomato under varying temperature and leaf wet duration, and evaluates fungicide efficacy over time.

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

The paper describes a novel bacterium capable of fermenting dichloromethane to acetate, providing insights into anaerobic DCM degradation and its metabolic pathways.

The paper investigates the dynamic multi-OMICs of glioblastoma and identifies sensitivity to neddylation inhibition, though the manuscript was withdrawn due to un reproducible findings.

This paper introduces a label-free volumetric imaging technique for thick-tissue slides with subcellular resolution, demonstrating its ability to visualize various tumor types and pathologies.

This study identifies novel Streptomyces strains and phages with potential for antibiotic discovery and genetic manipulation.

This paper introduces Proxy-ResNeXt-CBAM, a metric learning network for chromosome classification and retrieval in karyotyping, achieving high accuracy and effective clustering of embeddings.

The paper shows that spontaneous polyploids and antimutator clones outcompete each other in mutator yeast cultures, with polyploids dominating in haploid and antimutators in diploid settings.

This study uses SWATH-MS to comprehensively profile plasma extracellular vesicles from glioma patients, identifying potential biomarkers that reflect glioma subtype and aggressiveness.