M. Sun

The paper identifies OsMKK1 as a direct target of OsDMI3 and shows that OsDMI3-mediated phosphorylation of OsMKK1 is crucial for ABA signaling and stress responses.

The paper uses cryo-EM to reveal how TRAP1 interacts with SdhB folding intermediates, showing client binding induces structural changes in TRAP1 and provides insights into its role in mitochondrial function.

This paper introduces FSEC-Nb, a method using nanobody technology to screen membrane protein expression without GFP fusion, successfully identifying ZAC orthologs and SARS-CoV-2 membrane proteins with high monodispersity.

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

This study identifies phosphorylated residues in RBM20, showing their role in splicing control and protein shuttling, and links their mutation to cardiac dysfunction.

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

This paper develops a potent synthetic nanobody that neutralizes SARS-CoV-2 by locking its Spike protein in an inactive conformation, enabling aerosol delivery as a prophylactic or therapeutic agent.

This study demonstrates that customized speckle patterns can achieve three times higher spatial resolution than the diffraction limit in parallelized nonlinear pattern-illumination microscopy.

This study identifies lineage-specific transcription factors and super-enhancers driving neuroblastoma self-renewal and differentiation using ATRA treatment and CRISPR screening.

The paper determines cryo-EM structures of Hsp90:Aha1 complexes in multiple states to reveal a multistep activation mechanism where Aha1 accelerates ATP hydrolysis and induces conformational changes in Hsp90.

This study investigates the effect of hydrogen inhalation on SIgA, PIgR, and cytokines in a COPD rat model, finding improved expression of SIgA and related factors with higher hydrogen concentrations.

The paper identifies a ROS-responsive GGGCC motif regulated by snoRNP in Arabidopsis and shows its conservation in mouse and human genomes.

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

This study characterizes the molecular features and immune profile of sarcomatoid and rhabdoid renal cell carcinoma, showing their responsiveness to immune checkpoint inhibitors and identifying key genetic and transcriptional determinants.

This study investigates how formaldehyde fixation and imaging conditions affect the photophysics of mEos3.2 in fission yeast cells, providing a guide for quantitative imaging and counting of mEos3.2-tagged molecules.

The paper develops a DIVA strategy using epitope-containing short peptides (ECSPs) to differentiate vaccinated from infected animals, showing distinct IgG serodynamics that enable effective monitoring.

This study examines how incomplete sampling affects diversification rate estimates in rosids and finds that no method is fully robust to poor sampling, with BAMM being least sensitive to moderate missing taxa.

The paper constructs a five-locus supermatrix from GenBank data to explore rosid phylogeny, finding improved resolution but also highlighting sampling biases and limitations in current data.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study investigates diversification patterns in Annonaceae, finding that traits like liana habit and pollinator trapping correlate with higher diversification rates, while pollen aggregation and anther septation are linked to lower rates.

This paper compares purpose-built and synthesis phylogenies for community phylogenetic analyses, finding synthesis trees yield comparable results with less effort.

This paper uses time-resolved cryo-EM to directly observe the transition of bacterial release factors RF1 and RF2 from a compact to extended conformation during translation termination.

This study examines the sterilization effects of cavitation-shock interactions on marine Vibrio sp. through experimental and modeling approaches.

The paper identifies the N-cadherin interactome in primary cardiomyocytes using proximity proteomics, revealing over 350 proteins, many unique to CDH2.

This paper shows Bacillus thuringiensis uses Cry toxins and PlcR-regulated virulence factors to disrupt C. elegans intestinal epithelial junctions, enabling successful infection.

This study develops a porcine ex vivo model of pigmentary glaucoma, showing intraocular hypertension, pigment accumulation, and impaired phagocytosis in trabecular meshwork cells, with RhoA identified as a key regulator.