S. Zhou

This study shows that AAV6 and AAV9 vaccines induce cellular immunity protecting mice from SARS-CoV-2 pneumonia without relying on neutralizing antibodies.

The paper creates an isogenic cell line panel for drug screening, finding that most lines did not fully inactivate genes but a subset had biallelic disruptions, enabling drug response testing.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

This study identifies a maize inbred line, Xi502, that mounts effective defense against fall armyworm, showing distinct transcriptomic and elicitation responses compared to the susceptible line B73.

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

The paper studies a rare bamboo rhizome phenomenon with excessive shoots, analyzing its associated microbiome and finding correlations between bacterial genera and shoot numbers.

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.

The paper shows that structural variants causing cis-regulatory element hijacking have a greater impact on gene expression than changes in three-dimensional chromatin topology in primary prostate cancer.

This paper introduces a trait-based optimality theory that unifies stomatal responses and plant biochemical acclimation, validated with experimental data from 18 species.

This paper introduces TASEC, a method that enhances protein labeling and detection by using split enzyme complementation with orthogonal tags, demonstrating applications in cell enrichment and interaction studies.

The paper withdraws due to potential data analysis artefacts affecting conclusions about functional structure and ecosystem multifunctionality.

The paper improves split fluorescent protein systems for better complementation efficiency and signal amplification in mammalian cells.

The paper generates a HEK-293T cell line expressing murine GM-CSF and shows it supports dendritic cell and alveolar macrophage differentiation as an alternative to commercial GM-CSF.

This study examines HIV-1 compartmentalization in semen of men with and without STI-associated urethritis, finding stable viral populations and limited replication despite STI treatment.

This study determines the structural basis for hormone-controlled antibiotic production in Actinobacteria by solving the X-ray structure of an MmfR-AHFCA complex and elucidating DNA release mechanisms.

This study shows that CTP synthase forms cytoophidia in archaea, extending the known presence of these structures to all three domains of life.

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

This study identifies the COMPASS-like complex in M. oryzae and shows it regulates H3K4me3-mediated gene expression critical for fungal development and pathogenesis.

This study characterizes carbapenem-resistant Klebsiella pneumoniae isolates, identifying ST11 as the main type and blaKPC-2 as the dominant carbapenemase gene.

This study shows that GLUT1 inhibition reduces growth of RB1-positive TNBC cells with high glycolytic activity and low OXPHOS, suggesting a therapeutic target in this subset.

This study identifies gut microbiome biomarkers associated with obesity in Shenzhen adolescents and finds gender-specific differences in microbiome composition and function.

The paper identifies Streptomyces sp. S816 as a pentamycin producer and shows that the ptnJ gene encodes a cytochrome P450 responsible for converting filipin III to pentamycin.

The paper shows that most of the long-lived HIV-1 latent reservoir forms near the time of antiretroviral therapy initiation, not continuously during untreated infection.

This paper identifies a stable expression hot spot in Chinese hamster ovary cells using a lentivirus-based random integration method and validates its long-term expression stability.

The paper presents a set of 25 chemical probes targeting human bromodomains and demonstrates their utility in studying muscle cell differentiation and triple negative breast cancer.

This study investigates the effect of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae, showing increased 1,3-PDO production and altered byproduct formation.

This study uses metagenomic sequencing to identify pathogens in culture-negative infective endocarditis cases, providing antimicrobial resistance profiles without culturing.

The paper identifies two antifungal metabolites in maize roots and shows ethylene signaling regulates their ratio, affecting resistance to Fusarium graminearum.